Detail

Keywords

Skin

Research group(s)

• Cellular and Molecular Immunobiology of the Skin
  Head: Adelheid Elbe-Bürger
  Research Area: Investigations about the physiology of the human skin immune system and the origin, relationship and function of skin leukocytes in health and disease applying cutting edge technology.
  Members:
  Adelheid Elbe-Bürger

Research interests

Investigations about the physiology of the human skin immune system and the origin, relationship and function of skin leukocytes in health and disease.

Techniques, methods & infrastructure

State-of-the-art basic methodologies in cellular and molecular biology such as cell culture, functional and differentiation assay, ex vivo human skin (wound) models, ELISA, (immuno)histology, immunofluorescence, Western blot, cytokine array, FACS, CLSM, quantitative-RT-PCR.

Grants

• Development of adaptive human skin immunity (2018)
  Source of Funding: FWF (Austrian Science Fund), Stand-Alone Project
  Principal Investigator
• Molecular, Cellular and Clinical Allergology (MCCA), Faculty Member (2012)
  Source of Funding: FWF (Austrian Science Fund), PhD Program
  Principal Investigator

Selected publications

1. Cichoń, M.A. et al. (2022) ‘Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells’, eLife, 11. Available at: http://dx.doi.org/10.7554/elife.80578.
2. Reitermaier, R. et al. (2021) `αβγδ T cells play a vital role in fetal human skin development and immunity’, Journal of Experimental Medicine, 218(4). Available at: http://dx.doi.org/10.1084/jem.20201189.
3. McGovern, N. et al., 2017. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature, 546(7660), pp.662-666. Available at: http://dx.doi.org/10.1038/nature22795.
4. Tajpara, P. et al. (2019) ‘A Preclinical Model for Studying Herpes Simplex Virus Infection’, Journal of Investigative Dermatology, 139(3), pp. 673–682. Available at: http://dx.doi.org/10.1016/j.jid.2018.08.034.
5. Schuster, C. et al., 2009. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. The Journal of Experimental Medicine, 206(1), pp.169-181. Available at: http://dx.doi.org/10.1084/jem.20081747.