The interest of my research is focused on pediatric brain tumors, especially in the recurrent situation. The primary research interest is the identification of drivers of the disease, mainly in the CSF, and particular targeted on medulloblastoma and the identification of biological factors that lead to recurrence. The basic and translational research is focused on the microenvironment of tumors, especially the CSF, with the key aspects of antiangiogenic therapy and intraventricular therapy.
The clinical research centers on the development of new (targeted) therapies for children with brain tumors. We initiated the MEMMAT trial (Medulloblastoma European Multitarget Metronomic Anti-Angiogenic Trial), an academic phase II study for patients with recurrent or progressive medulloblastoma (ClinicalTrials.gov Identifier: NCT01356290).
- Reichl, B. et al., 2020. Determination of a Tumor-Promoting Microenvironment in Recurrent Medulloblastoma: A Multi-Omics Study of Cerebrospinal Fluid. Cancers, 12(6), p.1350. Available at: http://dx.doi.org/10.3390/cancers12061350.
- Hovestadt, V. et al., 2019. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature, 572(7767), pp.74–79. Available at: http://dx.doi.org/10.1038/s41586-019-1434-6.
- Filbin, M.G. et al., 2018. Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science, 360(6386), pp.331–335. Available at: http://dx.doi.org/10.1126/science.aao4750.
- Peyrl, A. et al., 2014. Safety of Ommaya reservoirs in children with brain tumors: a 20-year experience with 5472 intraventricular drug administrations in 98 patients. Journal of Neuro-Oncology, 120(1), pp.139–145. Available at: http://dx.doi.org/10.1007/s11060-014-1531-1.
- Peyrl, A. et al., 2011. Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors. Pediatric Blood & Cancer, 59(3), pp.511–517. Available at: http://dx.doi.org/10.1002/pbc.24006.