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Christoph Binder
Christoph Binder, MD, PhDHead: Nutritional Medicine (Growth and Body Composition), Deputy-Head: Neonatal Intensive Care Unit (NICU E10)

Comprehensive Center for Pediatrics
Position: Consultant

christoph.a.binder@muv.ac.at

Keywords

Critical Care; Enteral Nutrition; Enterocolitis, Necrotizing; Fetal Growth Retardation; Growth; Growth and Development; Individualized Medicine; Malnutrition; Milk, Human; Nutritional and Metabolic Diseases; Nutritional Status; Parenteral Nutrition

Research group(s)

  • Nutritional Medicine
    Research Area: The multidisciplinary research group has a focus on neonatal and pediatric nutrition and its effect on long term health including growth, body composition, neurodevelopment and cardiovascular health. Furthermore, the research team focus on human milk science and individualized and personalized nutrition. The research team take part in several national and international randomized controlled trials on neonatal and pediatric nutrition.
    Members:

Research interests

Nutritional Medicine (Growth and Body Composition) Head: Christoph Binder, MD, PhD

Members: Karin Harreiter (Study Nurse); Ap. Prof.in Mag.a Dr.in Dr.in Alexandra Thajer, MSc. MBA (Nutritionist); Theresa Kainz, MD; Susanne Kirschenhofer; MD Elisabeth Calek, MD

The multidisciplinary research group has a focus on neonatal and pediatric nutrition and its effect on growth, body composition, neurodevelopment and cardiovascular health. Furthermore, the research team focus on human milk science and individualized and personalized nutrition.

Techniques, methods & infrastructure

·       Body Composition measured by air displacement plethysmography (Pea Pod®)

·       Human Milk Analyzer (HMA) (MIRIS AB®)

Ongoing trials (PI: Christoph Binder)  

  • Effects of an exclusive human-milk diet in preterm neonates on early vacular aging risk factors (NEOVASC Study) – A randomized-multicentre-controlled-trial  
  • High-dose oral vitamin A supplementation of 5000 IU/kg/d versus placebo for 28 days for preventing BPD or death in preterm infants (NEOVITA Study) - A prospective-multicentre-double blind-lacebo-controlled-trial  
  • Does mucous fistula refeeding after enterostomy creation reduce the time to full enteral feeds after enterostomy closure? (MUC-Fire Study) - A randomized multicentre-controlled-trial  
  • Body Composition and Growth and its effect on NEC and Brain Maturation in preterm infants. - Observational-prospective-studies in preterm infants  

Further trials: 

  • Prophylactic treatment of the ductus arteriosus in preterm infants by acetaminophen (TREOCAPA Study) - A randomized-multicentre-controlled-trial  
  • A Monoclonal antibody with an extended half-life against RS virus, in preterm and term infants (MELODY Study) - A prospective-multicentre-double blind-placebo-controlled-trial

Grants

  • Effects of an exclusive human-milk diet in preterm neonates on early vacular aging risk factors (NEOVASC Study) (2021)
    Source of Funding: Medical University of Vienna, VASCage (Research Centre on Vascular Ageing and Stroke)
    Principal Investigator
  • Does mucous fistula refeeding after enterostomy creation reduce the time to full enteral feeds after enterostomy closure? (MUC-Fire Study) - A randomized multicentre controlled trial (2018)
    Source of Funding: Medical University of Vienna, German Research Foundation (DFG)
    Coordinator of the collaborative project

Selected publications

  1. Binder, C. et al. (2021) ‘Association between Fat-Free Mass and Brain Size in Extremely Preterm Infants’, Nutrients, 13(12), p. 4205. Available at: https://doi.org/10.3390/nu1312420.
  2. A mixed lipid emulsion containing fish-oil for parenteral nutrition of preterm infants: No impact on visual neuronal conduction. Nutrients 2021 Nov,13(12),4241. Christoph Binder, Hannah Schned, Nicholas Longford, Eva Schwindt, Margarita Thanhaeuser, Alexandra Thajer, Katharina Goeral, Matteo Tardelli, David Berry, Lukas Wisgrill, David Seki, Angelika Berger, Katrin Klebermass-Schrehof, Andreas Repa, Vito Giordano. IF: 5,7
  3. A mixed lipid emulsion containing fish oil and its effect on electrophysiological brain maturation in infants of extremely low birth weight: A secondary analysis of a randomized clinical trial. The Journal of Pediatrics 2019 Apr 25. 211:46-53.e2. Christoph Binder, Vito Giordano, Margarita Thanhaeuser, Alexandra Kreissl, Mercedes Huber-Dangl, Nicholas Longford, Nadja Haiden, Angelika Berger, Andreas Repa, Katrin Klebermass-Schrehof. IF: 3,6
  4. Body composition following necrotising enterocolitis in preterm infants. Neonatology. 2018;113(3):242-248. Christoph Binder, Nicholas Longford, Chris Gale, Neena Modi, Sabita Uthaya. IF: 4.0
  5. Extremely preterm infants have a higher fat mass percentage in comparison to very preterm infants at term-equivalent age. Front. Pediatr. 2020 Mar 10;8:61. Marlies Bruckner, Zahra Khan, Christoph Binder, Nicholas Morris, Bernadette Windisch, Sandra Holasek, Bernd Urlesberger. IF: 3,4