Keywords
Medical Physics; Molecular Imaging; Positron-Emission Tomography
Research group(s)
- Preclinical Imaging Lab
Members:
Research interests
My main research currently focuses on quantitative preclinical imaging using microPET/CT and microPET/MRI mostly in oncology and neurology. Moreover, I am interested in standardization of preclinical imaging procedures and protocols and I also perform pharmacokinetic modeling of obtained PET data.
Techniques, methods & infrastructure
microPET; microPET/CT; microPET/MR
Grants
- Comprehensive STRategies to tacKIE malignant tumors: from nanomedicine and theranostics to precision medicine / STRIKE (2023)
Source of Funding: EU, Horizon 2020
Principal Investigator - Development of a “Chelate to Release” Labeling Platform for Synthesis of high molar activity Radiopharmaceuticals (2021)
Source of Funding: FFG (Austrian Research Promotion Agency), Bridge
Principal Investigator - Combination therapy in combating cholangiocarcinoma (2020)
Source of Funding: NÖ Forschungs- und Bildungsges.m.b.H. (NFB), Life Science Call 2019
Coordinator of the collaborative project - HYPERDIAMOND (2016)
Source of Funding: EU, PHC-11-2015
Principal Investigator - Tau Imaging in a Transgenic Animal Model (2015)
Source of Funding: FFG (Austrian Research Promotion Agency), Bridge
Coordinator of the collaborative project
Selected publications
- Zachhuber, L. et al. (2024) ‘Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [18F]FDG-PET/MRI’, Cancers, 16(14), p. 2591. Available at: https://doi.org/10.3390/cancers16142591.
- Filip, T. et al. (2021) ‘Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling’, Alzheimer’s Research & Therapy, 13(1). Available at: https://doi.org/10.1186/s13195-021-00916-2.
- Osborne, D.R. et al. (2016) ‘Guidance for Efficient Small Animal Imaging Quality Control’, Molecular Imaging and Biology, 19(4), pp. 485–498. Available at: http://dx.doi.org/10.1007/s11307-016-1012-3.
- Denk, C. et al. (2014) ‘Development of a18F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging’, Angewandte Chemie International Edition, 53(36), pp. 9655–9659. Available at: http://dx.doi.org/10.1002/anie.201404277.
- Kuntner, C. and Stout, D. (2014) ‘Quantitative preclinical PET imaging: opportunities and challenges’, Frontiers in Physics, 2. Available at: http://dx.doi.org/10.3389/fphy.2014.00012.