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Detail

Florian Gruber
Assoc. Prof. Priv.-Doz. Mag. Dr. Florian GruberPI, Head of CDL SKINMAGINE

Department of Dermatology
Position: Associate Professor

ORCID: 0000-0003-1094-5641
T +43 1 40400 73734
florian.gruber@meduniwien.ac.at

Further Information

Keywords

Aging; Oxidative Stress; Phospholipids; Skin Aging

Research group(s)

Research interests

My research is focussed on the role of bioactive lipid mediators in skin biology. We investigate the generation, the biochemistry and the signaling of lipid mediators in basic and translational research projects. 

Techniques, methods & infrastructure

Lipid Biology, Lipid analysis, Multimodal Imaging, Automated Tissue Analysis, Organotypic Skin Models

Selected publications

  1. Narzt, M.-S. et al., 2019. A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids. Redox Biology, 20, pp.467-482. Available at: http://dx.doi.org/10.1016/j.redox.2018.11.006.
  2. Ni, C. et al., 2016. Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators. The International Journal of Biochemistry & Cell Biology, 81, pp.375-382. Available at: http://dx.doi.org/10.1016/j.biocel.2016.10.006.
  3. Song, X. et al., 2017. Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo. Redox Biology, 11, pp.219-230. Available at: http://dx.doi.org/10.1016/j.redox.2016.12.015.
  4. Narzt, M.-S. et al., 2021. Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors. Journal of Investigative Dermatology, 141(4), pp.993–1006.e15. Available at: http://dx.doi.org/10.1016/j.jid.2020.11.020.
  5. Kremslehner, C. et al., 2020. Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents – Implications for oxidative UV damage. Redox Biology, 37, p.101583. Available at: http://dx.doi.org/10.1016/j.redox.2020.101583.