Department of Neurology
Position: Doctor-in-training
ORCID: 0000-0002-4146-5870
nik.krajnc@meduniwien.ac.at
Keywords
Disease Progression; Glial Fibrillary Acidic Protein; Magnetic Resonance Imaging; Multiple Sclerosis; Neurofilament Proteins; Tomography, Optical Coherence
Research group(s)
- Multiple Sclerosis
Members: - Idiopathic intracranial hypertension
Head: Gabriel Bsteh
Research Area: Improving diagnosis, risk stratification and treatment of patients with Idiopathic Intracranial Hypertension (IIH)
Members:
Research interests
My primary research interest centers on identifying and validating biomarkers of disease progression in multiple sclerosis, with a particular emphasis on both imaging modalities—such as magnetic resonance imaging (MRI) and optical coherence tomography (OCT)—and serum biomarkers, including serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP). In addition, my secondary area of investigation focuses on idiopathic intracranial hypertension (IIH), exploring innovative strategies to enhance the management and treatment outcomes of this challenging condition.
Selected publications
- Krajnc, N. et al. (2022) ‘Association of paramagnetic rim lesions and retinal layer thickness in patients with multiple sclerosis’, Multiple Sclerosis Journal, 29(3), pp. 374–384. Available at: https://doi.org/10.1177/13524585221138486.
- Krajnc, N. et al. (2023) ‘Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis’, Multiple Sclerosis Journal, 29(11–12), pp. 1406–1417. Available at: https://doi.org/10.1177/13524585231197954.
- Krajnc, N. et al. (2024) ‘Plasma calcitonin gene-related peptide levels in idiopathic intracranial hypertension: an exploratory study’, The Journal of Headache and Pain, 25(1). Available at: https://doi.org/10.1186/s10194-024-01799-y.
- Krajnc, N. et al. (2023) ‘Treatment with GLP-1 receptor agonists is associated with significant weight loss and favorable headache outcomes in idiopathic intracranial hypertension’, The Journal of Headache and Pain, 24(1). Available at: https://doi.org/10.1186/s10194-023-01631-z.
- Hofmann, A. et al. (2023) ‘Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis’, Acta Neuropathologica, 146(5), pp. 707–724. Available at: https://doi.org/10.1007/s00401-023-02627-4.