Detail

Keywords

Aging, Premature; Atherosclerosis; Macrophages; Monocytes

Research group(s)

• RG Hohensinner
  Head: Philipp Hohensinner
  Research Area: cardiovascular biology, monocyte and macrophage biology, virus infection, lung biology
  Members:
  Philipp Hohensinner

Research interests

My current main research interest is to analyze the function and functional changes of the innate immune system in health and disease with a special focus on cardiovascular disease.

Techniques, methods & infrastructure

• In vitro cell culture,
• animal models,
• flow cytometry,
• molecular biology techniques
• automated tissue section analysis
• RNA sequencing

Selected publications

1. Haider, P. et al. (2020) ‘Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets’, Arteriosclerosis, Thrombosis, and Vascular Biology, 40(9), pp. 2265–2278. Available at: http://dx.doi.org/10.1161/atvbaha.120.314883.
2. Hohensinner, P. et al. (2021) 'Alternative activation of human macrophages enhances tissue factor expression and production of extracellular vesicles', Haematologica 2021 available at 10.3324/haematol.2019.220210
3. Lenz, M. et al. (2022) ‘Pharmacologic modulation of intracellular Na+concentration with ranolazine impacts inflammatory response in humans and mice’, Proceedings of the National Academy of Sciences, 119(29). Available at: https://doi.org/10.1073/pnas.2207020119.
4. Hohensinner, P.J. et al. (2017) ‘PAI-1 (Plasminogen Activator Inhibitor-1) Expression Renders Alternatively Activated Human Macrophages Proteolytically Quiescent’, Arteriosclerosis, Thrombosis, and Vascular Biology, 37(10), pp. 1913–1922. Available at: http://dx.doi.org/10.1161/atvbaha.117.309383.
5. Kral-Pointner, J.B. et al. (2024) ‘Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice’, Arteriosclerosis, Thrombosis, and Vascular Biology, 44(4), pp. 954–968. Available at: https://doi.org/10.1161/atvbaha.123.320016.