Detail

Keywords

Drug Development; Genomics; Host-Pathogen Interactions; Microbiology; Proteomics; Transcriptome

Research group(s)

• Molecular parasitology
  Head: Julia Walochnik
  Research Area: Acanthamoeba infections, amoebae as hosts for bacteria, vector-borne parasites, molecular phylogeny
  Members:
  Iwona Lesiak-Markowicz
  Martina Köhsler
  Rounik Mazumdar
  Alvie Loufouma Mbouaka
  Julia Walochnik
  Edwin Kniha

Research interests

Main research interest encompasses the understanding of the molecular biology of infectious pathogens and their interaction with the host. The overall aim is to elucidate virulence factors, decipher host-pathogen interaction, investigate host immune response and devise strategies for drug development.

Selected publications

1. Mazumdar, R. et al. (2017) ‘Establishment of a de novo Reference Transcriptome of Histomonas meleagridis Reveals Basic Insights About Biological Functions and Potential Pathogenic Mechanisms of the Parasite’, Protist, 168(6), pp. 663–685. Available at: https://doi.org/10.1016/j.protis.2017.09.004.
2. Mazumdar, R. et al. (2019) ‘Molecular characterization of Histomonas meleagridis exoproteome with emphasis on protease secretion and parasite-bacteria interaction’, PLOS ONE. Edited by J. Parkinson, 14(2), p. e0212429. Available at: https://doi.org/10.1371/journal.pone.0212429.
3. Shivarathri, R. et al. (2020) ‘The Two-Component Response Regulator Ssk1 and the Mitogen-Activated Protein Kinase Hog1 Control Antifungal Drug Resistance and Cell Wall Architecture of Candida auris’, mSphere. Edited by A.P. Mitchell, 5(5). Available at: https://doi.org/10.1128/msphere.00973-20.
4. Shivarathri, R. et al. (2022) ‘Comparative Transcriptomics Reveal Possible Mechanisms of Amphotericin B Resistance in Candida auris’, Antimicrobial Agents and Chemotherapy, 66(6). Available at: https://doi.org/10.1128/aac.02276-21.
5. Loufouma Mbouaka, A. et al. (2023) ‘Assessing Acanthamoeba cytotoxicity: comparison of common cell viability assays’, Frontiers in Microbiology, 14. Available at: https://doi.org/10.3389/fmicb.2023.1175469.