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Sabine Flicker
Dr Sabine Flicker

Center for Pathophysiology, Infectiology and Immunology (Institute of Pathophysiology and Allergy Research)
Position: Associate Professor

ORCID: 0000-0003-4768-8693
T +43 1 40400-51150
sabine.flicker@meduniwien.ac.at

Further Information

Keywords

Allergy and Immunology; Antibodies

Research group(s)

Research interests

Molecular, immunological and structural characterization of allergen-specific antibodies and nanobodies to answer fundamental questions regarding the interaction allergen/IgE antibodies as well as to develop tools for diagnosis, prevention and treatment of allergy. 

Techniques, methods & infrastructure

Our expertise includes a broad spectrum of state-of-the-art-methodologies in molecular and cellular biology and immunology, e.g. generation of antibody/nanobody libraries, phage display technology, isolation and characterization of monoclonal antibodies/nanobodies, cell culture, mediator release experiments, DNA cloning, ELISA, immunoblotting, Biacore, mouse models.

Grants

Selected publications

  1. Zettl, I. et al. (2022) ‘Generation of high affinity ICAM-1-specific nanobodies and evaluation of their suitability for allergy treatment’, Frontiers in Immunology, 13. Available at: http://dx.doi.org/10.3389/fimmu.2022.1022418.
  2. Zettl, I. et al. (2021) ‘Isolation of nanobodies with potential to reduce patients’ IgE binding to Bet v 1’, Allergy, 77(6), pp. 1751–1760. Available at: http://dx.doi.org/10.1111/all.15191.
  3. Flicker, S., Zettl, I. and Tillib, S.V. (2020) ‘Nanobodies—Useful Tools for Allergy Treatment?’, Frontiers in Immunology, 11. Available at: http://dx.doi.org/10.3389/fimmu.2020.576255.
  4. Gadermaier, E. et al. (2018) ‘Isolation of a high-affinity Bet v 1-specific IgG-derived ScFv from a subject vaccinated with hypoallergenic Bet v 1 fragments’, Allergy, 73(7), pp. 1425–1435. Available at: http://dx.doi.org/10.1111/all.13394.
  5. Madritsch, C. et al. (2015) ‘Antibody conjugates bispecific for intercellular adhesion molecule 1 and allergen prevent migration of allergens through respiratory epithelial cell layers’, Journal of Allergy and Clinical Immunology, 136(2), pp. 490-493.e11. Available at: http://dx.doi.org/10.1016/j.jaci.2015.01.006.