Biomimetic Materials; Nerve Regeneration; Peripheral Nerves; Regenerative Medicine; Schwann Cells; Silk
- ARGE Radtke
Research Area: cell based therapies and spider silk conduits for peripheral nerve regeneration
Within the scope of my research, I try to unravel the unique properties of spider silk responsible for its exceptional ability to support peripheral nerve regeneration. I combine methods such as mass spectrometry, electron microscopy, and atomic force microscopy, with in vitro studies to determine the crucial chemical, structural, and morphological properties of spider silk.
Techniques, methods & infrastructure
- Primary Rodent Cell Culture
- Live Cell Imaging
- Confocal Laser Scanning Microscopy
- Atomic Force Microscopy
- Electron Microscopy
- Proteomics (nLC-nESI-MS/MS)
- Transcriptomics (RNASeq, Microarray)
- Borger, A. et al. (2022) ‘How miRNAs Regulate Schwann Cells during Peripheral Nerve Regeneration—A Systemic Review’, International Journal of Molecular Sciences, 23(7), p. 3440. Available at: http://dx.doi.org/10.3390/ijms23073440.
- Bergmann, F. et al. (2022) ‘The properties of native Trichonephila dragline silk and its biomedical applications’, Biomaterials Advances, 140, p. 213089. Available at: http://dx.doi.org/10.1016/j.bioadv.2022.213089.