Severin Mairinger
Department of Clinical Pharmacology
Position: Research Associate (Postdoc)
ORCID: 0000-0001-5094-9351
severin.mairinger@meduniwien.ac.at
Keywords
ATP-Binding Cassette Transporters; Blood-Brain Barrier; Drug Development; Drug Interactions; Lung; Membrane Transport Proteins; Pharmacokinetics; Pharmacology, Clinical; Positron-Emission Tomography; Tissue Distribution
Research group(s)
- Section of Clinical Pharmacokinetics / Pharmacogenetics and Imaging
Head: Markus Zeitlinger
Research Area: Our main focus is the study of the drug distribution process by employing techniques to measure target site distribution directly, i.e. PET or microdialysis.
Members: - Translational Pharmacokinetic Imaging
Head: Oliver Langer
Members:
Selected publications
- Mairinger, S. et al. (2024) ‘Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates’, EJNMMI Radiopharmacy and Chemistry, 9(1). Available at: https://doi.org/10.1186/s41181-024-00265-z.
- Mairinger, S. et al. (2023) ‘[11C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier’, Journal of Cerebral Blood Flow & Metabolism, 44(1), pp. 142–152. Available at: https://doi.org/10.1177/0271678x231202336.
- Mairinger, S. et al. (2022) ‘Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats’, Journal of Controlled Release, 349, pp. 109–117. Available at: https://doi.org/10.1016/j.jconrel.2022.06.065.
- Mairinger, S. et al. (2022) ‘Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition’, Expert Opinion on Drug Delivery, 19(12), pp. 1561–1575. Available at: https://doi.org/10.1080/17425247.2022.2137143.
- Mairinger, S. et al. (2020) ‘Assessing the Activity of Multidrug Resistance–Associated Protein 1 at the Lung Epithelial Barrier’, Journal of Nuclear Medicine, 61(11), pp. 1650–1657. Available at: https://doi.org/10.2967/jnumed.120.244038.