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Tim Hendrikx
Tim Hendrikx, PhDPI at the Department of Laboratory Medicine

Department of Laboratory Medicine

T +43 1 40400 - 73640
tim.hendrikx@meduniwien.ac.at

Keywords

Alcohol-Related Disorders; Atherosclerosis; Fatty Liver; Fatty Liver, Alcoholic

Research group(s)

Research interests

  • Decipher the cellular and molecular mechanisms involved in the progression of chronic steatotic liver diseases
  • Study the gut-liver axis during metabolic dysfunction and alcohol-related liver disease
  • Peptide therapeutics as tool to modulate immunity during fatty liver disease

Techniques, methods & infrastructure

  • Mouse models for steatotic liver disease (MASLD, MetALD, ALD) and atherosclerosis.
  • -omics to discover disease-relevant targets (single cell RNA seq, spatial transcriptomics, metabolomics, ...)
  • immunohistochemistry
  • flow cytometry
  • elisa
  • cell culture

Selected publications

  1. Hendrikx, T. et al. (2023) ‘Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice’, Gut, 72(10), pp. 1959–1970. Available at: https://doi.org/10.1136/gutjnl-2022-328265.
  2. Hendrikx, T. et al. (2022) ‘Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH’, Journal of Hepatology, 77(5), pp. 1373–1385. Available at: https://doi.org/10.1016/j.jhep.2022.06.004.
  3. Hendrikx, T. et al. (2018) ‘Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice’, Gut, 68(8), pp. 1504–1515. Available at: https://doi.org/10.1136/gutjnl-2018-317232.
  4. Busch, C.J. et al. (2017) ‘Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice’, Hepatology, 65(4), pp. 1181–1195. Available at: https://doi.org/10.1002/hep.28970.
  5. Hendrikx, T. et al. (2015) ‘Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr−/− mice’, Journal of Hepatology, 62(2), pp. 430–436. Available at: https://doi.org/10.1016/j.jhep.2014.09.027.