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Wolfgang Mikulits
Ao. Prof. Dr. Mag. Wolfgang MikulitsGroup Leader and Head of Research Focus forTumor Progression and Metastasis

Center for Cancer Research, Department of Medicine I
Position: Associate Professor

ORCID: 0000-0003-4612-7106
T +43 1 40160 57527
wolfgang.mikulits@meduniwien.ac.at

Further Information

Keywords

Biomarkers, Pharmacological; Epithelial-Mesenchymal Transition; Neoplasm Metastasis; Signal Transduction

Research interests

  • Mechanisms of epithelial to mesenchymal transition and liver carcinoma progression
  • Tumor-promoting cell signaling in liver cancer metastasis
  • Biomarker of liver cancer
  • Models of liver carcinoma progression
  • Selective translation control during tumor progression and metastasis

Techniques, methods & infrastructure

  • Molecular cloning
  • Cell culture of primary cells and cell lines
  • 3-dimensional culture
  • Real-time qPCR
  • RNA immunoprecipitation
  • Flow cytometric analysis
  • ELISA; Western blot; IHC; Confocal IF
  • CRISPR/Cas9; RNA interfence
  • Xenograft mouse models
  • Syngeneic mouse models
  • Invasion and metastasis assays
  • Transcriptome profiling
  • Proteomic profiling

Grants

  • International PhD Program in Translational Oncology (2019)
    Source of Funding: FWF (Austrian Science Fund), doc.funds Programme
    Principal Investigator
  • Role of Axl Receptor Shedding in Liver Cancer (2019)
    Source of Funding: FWF (Austrian Science Fund), Stande Alone Project
    Principal Investigator
  • Diagnostic and Prognostic Value of Soluble Axl in Hepatocellular Carcinoma (2015)
    Source of Funding: OeNB (Oesterreichische Nationalbank), Anniversary Fund
    Principal Investigator
  • Release of Soluble Axl and Gas6-Independent Axl Signaling in Hepatocellular Carcinoma (2015)
    Source of Funding: Herzfelder'sche Familienstiftung,
    Principal Investigator
  • Control of Pro- and Anti-Oncogenic Stat3 Activity in Hepatocellular Carcinoma (2012)
    Source of Funding: Herzfelder'sche Familienstiftung, Stand Alone Project
    Principal Investigator
  • IT-LIVER - Strategy to Inhibit TGF-beta in Liver Disease (project partner) (2012)
    Source of Funding: EU, FP7-PEOPLE-2012-ITN
    Principal Investigator
  • The Role of Axl in Hepatocellular Carcinoma Progression (2012)
    Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
    Principal Investigator
  • Cooperation of wnt beta-catenin during Hepatocellular Carcinoma Progression (2009)
    Source of Funding: City of Vienna, Hochschuljubiläumsstiftung
    Principal Investigator
  • Functional analysis of Laminin B1 IRES in cancer progression (2008)
    Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
    Principal Investigator
  • Migration and Anoikis during Hepatocellular Carcinoma Progression (2008)
    Source of Funding: City of Vienna, Hochschuljubiläumsstiftung
    Principal Investigator
  • RESOLVE Chronic Inflammation and Achieve Healthy Aging by Understanding Non-regenerative Repair (2008)
    Source of Funding: EU, HEALTH-F4-2008-202047
    Principal Investigator
  • The Impact of the Tumor Microenvironment in Liver Carcinoma Progression (2008)
    Source of Funding: Herzfelder'sche Familienstiftung, Stand Alone Project
    Principal Investigator
  • Liver cancer stemness and metastasis (2007)
    Source of Funding: FWF (Austrian Science Fund), Stand Alone Project
    Principal Investigator
  • Jak-Stat - Signalling from Basis to Disease (project part leader) (2005)
    Source of Funding: FWF (Austrian Science Fund), Special Research Programmes (SFB 28)
    Principal Investigator
  • Orthotope Transplantation von Hepatozyten zur Untersuchung der Tumor-suppressiven Wirkung von c-Fos während der Lebertumorigenese (2005)
    Source of Funding: City of Vienna, Hochschuljubiläumsstiftung
    Principal Investigator
  • Stats in Liver Fibrosis and Late Stage Heptocarcinogenesis (2005)
    Source of Funding: Herzfelder'sche Familienstiftung, Stand Alone Project
    Principal Investigator
  • PDGF signaling during hepatocellular tumor (2003)
    Source of Funding: OeNB (Oesterreichische Nationalbank), Anniversary Fund
    Principal Investigator
  • Molecular Mechanisms Involved in Hepatocellular Epithelial to Fibroblastoid Conversion (2002)
    Source of Funding: FWF (Austrian Science Fund), Stand Alone Project
    Principal Investigator
  • The Induction of Hepatocellular De-differentiation through the Cooperation of Ha-Ras and TGF-beta (2001)
    Source of Funding: Herzfelder'sche Familienstiftung, Stand Alone Project
    Principal Investigator

Selected publications

  1. Transforming Growth Factor-β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma. Hepatology, 69:222-236.
  2. Signaling of Axl via 14-3-3zeta Activates Autocrine Transforming Growth Factor-β Signaling in Hepatocellular Carcinoma. Hepatology, 61, 930-941.
  3. p19ARF/p14ARF controls oncogenic functions of Stat3 in hepatocellular carcinoma. Hepatology, 54, 164-172.
  4. PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression. Oncogene 26, 3395-3405.
  5. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness. J. Cell Sci. 15, 1189-1202.