Detail

Keywords

Allergy Diagnosis; Sublingual Immunotherapy

Research group(s)

• Pediatric Allergology and Pulmonology
  Research Area: Pediatric Allergology: Primary food allergies (IgE- and non-IgE-mediated),new markers of diagnosis (BAT), food challenges; allergen-specific preventive immuntherapy trial in 4 year old children Pediatric Pulmonology: cystic fibrosis treatment trials
  Members:
  Zsolt Szepfalusi

Research interests

• primary food allergies in children
• placebo-controlled, randomized, preventive allergen-specific immunotherapy in young children
• clinical studies in severe atopic dermatitis
• clinical studies in rare disease of the airways in children

Techniques, methods & infrastructure

• food challenges (clinical)
• other provocation tests (unspecific, specific)
• flow cytometry
• cell culture (proliferation, cytokine detection, inhibition assays)
• IgE immunoblotting

Grants

• Hydroxychloroquine in pediatric ILD (2017)
  Source of Funding: FWF (Austrian Science Fund), E-Rare Joint Transnational Call
  Principal Investigator

Selected publications

1. Román‐Carrasco, P. et al., 2019. Only α‐Gal bound to lipids, but not to proteins, is transported across enterocytes as an IgE‐reactive molecule that can induce effector cell activation. Allergy, 74(10), pp.1956–1968. Available at: http://dx.doi.org/10.1111/all.13873.
2. Ponce, M. et al., 2019. Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre‐school children. Allergy, 74(4), pp.780–787. Available at: http://dx.doi.org/10.1111/all.13658.
3. Moñino‐Romero, S. et al., 2019. Soluble Fcɛ RI  : a biomarker for IgE‐mediated diseases. Allergy. Available at: http://dx.doi.org/10.1111/all.13734.
4. Moñino-Romero, S. et al., 2018. The soluble isoform of human FcɛRI is an endogenous inhibitor of IgE-mediated mast cell responses. Allergy, 74(2), pp.236–245. Available at: http://dx.doi.org/10.1111/all.13567.