Detail

Keywords

Computational Modelling; Pharmacokinetics; Pharmacology, Clinical

Research group(s)

• Section of Clinical Pharmacokinetics / Pharmacogenetics and Imaging
  Head: Markus Zeitlinger
  Research Area: Our main focus is the study of the drug distribution process by employing techniques to measure target site distribution directly, i.e. PET or microdialysis.
  Members:
  Valentin al Jalali
  Severin Mairinger
  Alina Nussbaumer-Pröll
  Oliver Langer
  Iris Minichmayr

Techniques, methods & infrastructure

Nonlinear mixed-effects modelling (population pharmacokinetic-pharmacudynamic modelling and simualtions)

Selected publications

1. Minichmayr, I.K. et al. (2024) ‘Model-informed precision dosing: State of the art and future perspectives’, Advanced Drug Delivery Reviews, 215, p. 115421. Available at: https://doi.org/10.1016/j.addr.2024.115421.
2. Minichmayr, I.K. and Friberg, L.E. (2024) ‘Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation’, International Journal of Antimicrobial Agents, 64(2), p. 107236. Available at: https://doi.org/10.1016/j.ijantimicag.2024.107236.
3. Minichmayr, I.K. et al. (2024) ‘Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors’, Pediatric Drugs, 26(4), pp. 429–440. Available at: https://doi.org/10.1007/s40272-024-00624-y.
4. Minichmayr, I.K. et al. (2023) ‘Impact of Key Components of Intensified Ceftaroline Dosing on Pharmacokinetic/Pharmacodynamic Target Attainment’, Clinical Pharmacokinetics, 63(1), pp. 121–131. Available at: https://doi.org/10.1007/s40262-023-01325-4.
5. Minichmayr, I.K., Karlsson, M.O. and Jönsson, S. (2021) ‘Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety’, Pharmaceutical Research, 38(4), pp. 593–605. Available at: https://doi.org/10.1007/s11095-021-03024-w.