Biostatistics; Breast Neoplasms; Epidemiologic Studies; Gastrointestinal Neoplasms; Prostate
- Cancer epidemiology
- Circadian epidemiology
My main research interests are circadian and sleep epidemiology and specifically circadian disruption as a potential environmental and occupational cause of cancer. I have evaluated the association between night shift work and risk for common tumors such as breast and prostate cancer in a large multi-case-control study in Spain (MCC-Spain). I also have a strong interest in the underlying biological mechanisms involved in carcinogenesis and have described hormonal changes that occur after night work and might explain part of the increased cancer risk among night shift workers. I found that daily hormonal rhythms of melatonin and a wide range of sex steroid biomarkers are disrupted in real-life night workers. I am also interested in individual characteristics such as diurnal preference or chronotype that may modify shift work tolerance and thus the effects of night work on disease risk. My current research focuses on the effects of light-at-night and circadian disruption on gastrointestinal tumors and other chronic disease outcomes, e.g obesity. I will also be involved in the evaluation of new hypotheses related to the cross-generational effects of shift work and circadian disruption before and during pregnancy on child health.
Techniques, methods & infrastructure
All stages of epidemiological research including study design, coordination, collection of primary data, laboratory analyses (radioimmunoassay for 6-sulfatoxymelatonin measurement), data base management, statistical analyses (STATA and SPSS software) and manuscript preparation.
- Papantoniou K, Castano-Vinyals G, Espinosa A, Aragones N, Perez-Gomez B, Ardanaz E, Altzibar JM, Sanchez VM, Gomez-Acebo I, Llorca J, Munoz D, Tardon A, Peiro R, Marcos-Gragera R, Pollan M, Kogevinas M. Breast cancer risk and night shift work in a case-control study in a Spanish population. Eur J Epidemiol. 2015 Jul 24. PMID: 26205167
- Papantoniou K, Castano-Vinyals G, Espinosa A, Aragones N, Perez-Gomez B, Burgos J, Gomez-Acebo I, Llorca J, Peiro R, Jimenez-Moleon JJ, Arredondo F, Tardon A, Pollan M, Kogevinas M. Night shift work, chronotype and prostate cancer risk in the MCC-Spain case-control study Int J Cancer. 2015 Sep 1;137(5):1147-57. 2015 Jan 12.PMID: 25530021
- Papantoniou K, Pozo OJ, Espinosa A, Marcos J, Castano-Vinyals G, Basagana X, Ribas FC, Mirabent J, Martin J, Carenys G, Martin CR, Middleton B, Skene DJ, Kogevinas M. Circadian variation of melatonin, light exposure, and diurnal preference in day and night shift workers of both sexes. Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1176-86. 2014 May 8.PMID: 24812038
- Papantoniou K, Pozo OJ, Espinosa A, Marcos J, Castano-Vinyals G, Basagana X, Juanola Pages E, Mirabent J, Martin J, Such Faro P, Gasco Aparici A, Middleton B, Skene DJ, Kogevinas M. Increased and mistimed sex hormone production in night shift workers. Cancer Epidemiol Biomarkers Prev. 2015 May;24(5):854-63. 2015 Mar 3. PMID: 25737330
- Papantoniou K, Fito M, Covas MI, Munoz D, Schroder H.trans Fatty acid consumption, lifestyle and type 2 diabetes prevalence in a Spanish population. Eur J Nutr. 2010 Sep;49(6):357-64. doi: 10.1007/s00394-010-0093-z. Epub 2010 Feb 4. PMID: 20127343