Chemokines; Clinical virology ; Serology
- Comprehensive Serology and Chemokines in Clinical Virology
Serology plays an essential role in the diagnosis of diverse viral diseases. The aim of my research is to evaluate the diagnostic abilities of comprehensive serological assays (avidity assays, epitope type specificity tests, immunoblots) in clinical virology and to investigate whether T-cell associated chemokines may serve as clinical markers to evaluate the stage, course and severity of different virus infections.
A specific aim of my current research is to assess and evaluate antibody assays in SARS-CoV-2, Parvovirus B19 and Measles virus infections.
Techniques, methods & infrastructure
- Quantitative ELISAs and CLIAs
- Epitope-Type-Specifity (ETS) Assays
- IgG-avidity assays
- Diagnosis of SARS-CoV-2 infections and assessment of seroprevalence using antibody assays with the highest performance (2020)
Source of Funding: Medical Scientific Fund of the Mayor of the City of Vienna, CoVID19 Research
- Semmler, G. et al., 2020. Elevated CXCL10 serum levels in Measles virus primary infection and reinfection correlate with the serological stage and hospitalization status. The Journal of Infectious Diseases. Available at: http://dx.doi.org/10.1093/infdis/jiaa326.
- Traugott, M. et al., 2020. Performance of SARS-CoV-2 antibody assays in different stages of the infection: Comparison of commercial ELISA and rapid tests. The Journal of Infectious Diseases. Available at: http://dx.doi.org/10.1093/infdis/jiaa305.
- Weseslindtner, L. et al., 2020. Longitudinal assessment of the CXCL10 blood and urine concentration in kidney transplant recipients with BK polyomavirus replication—a retrospective study. Transplant International, 33(5), pp.555–566. Available at: http://dx.doi.org/10.1111/tri.13584.
- Weseslindtner, L. et al., 2016. The chemokine CXCL-10 is a marker for the infection stage in individuals with Parvovirus B19 DNAemia. Journal of Infectious Diseases, p.jiw509. Available at: http://dx.doi.org/10.1093/infdis/jiw509.
- Weseslindtner, L. et al., 2014. High CXCL-16 Levels Correlate With Symptomatic Disease in Lung Transplant Recipients With Human Cytomegalovirus Replication in the Allograft. American Journal of Transplantation, 14(10), pp.2406–2411. Available at: http://dx.doi.org/10.1111/ajt.12836.