Chemokines; Clinical virology ; T Cells
- T-cell responses and T-cell associated chemokines in clinical virology
Antiviral T-cell responses and chemokines that attract T-cells to the site of the infection are essential for an efficient control of viral replication. The aim of my research is to investigate whether antiviral T-cell responses and T-cell associated chemokines may serve as clinical markers to evaluate the stage, course and severity of different virus infections.
Techniques, methods & infrastructure
- Fluorescent Activated Cell Sorter Analysis,
- Standardized T-cell assays (i.e. QuantiFERON-assay),
- Quantitative chemokine ELISAs
- Weseslindtner L et al. Intrapulmonary Human Cytomegalovirus replication in lung transplant recipients is associated with a rise of CCL-18 and CCL-20 chemokine levels. Transplantation. 2016; in press
- Weseslindtner L et al. High CXCL-16 Levels Correlate With Symptomatic Disease in Lung Transplant Recipients With Human Cytomegalovirus Replication in the Allograft. Am J Transplant. 2014; 14: 2406-11.
- Weseslindtner L et al. Prospective Analysis of Human Cytomegalovirus DNAemia and Specific CD8+ T-Cell Responses in Lung Transplant Recipients. Am J Transplant. 2012; 12:2172-80.
- Weseslindtner L et al. Human cytomegalovirus infection in lung transplant recipients triggers a CXCL-10 response. Am J Transplant. 2011; 11:542-52.
- Weseslindtner L et al. Acute infection with a single hepatitis C virus strain in dialysis patients: Analysis of adaptive immune response and viral variability. J Hepatol. 2009; 50:693-704.