Chemokines; Clinical virology ; Serology
- Comprehensive Serology and Chemokines in Clinical Virology, Parvovirus B19 Research
Serology plays an essential role in the diagnosis of diverse viral diseases. The aim of my research is to evaluate the diagnostic abilities of comprehensive serological assays (avidity assays, epitope type specificity tests, immunoblots) in clinical virology and to investigate whether T-cell associated chemokines may serve as clinical markers to evaluate the stage, course and severity of different virus infections.
A specific aim of my current research is to assess and develop new diagnostic tools for Parvovirus B19 infection in pregnancy.
Techniques, methods & infrastructure
- Standardized T-cell assays (i.e. QuantiFERON-assay),
- Quantitative chemokine ELISAs
- Epitope-Type-Specifity (ETS) Assays
- IgG-avidity assays
- Multiplex analysis of Human Polyomavirus diversity in kidney transplant recipients with BK virus replication. Wang Y et al. J Clin Virol. 2019; 120:6-11.
- The Chemokine CXCL-10 Is a Marker of Infection Stage in Individuals With DNAemia Due to Parvovirus B19. Weseslindtner L et al. J Infect Dis 2017; 215:214-220.
- Intrapulmonary Human Cytomegalovirus replication in lung transplant recipients is associated with a rise of CCL-18 and CCL-20 chemokine levels. Weseslindtner L et al. Transplantation 2017; 101:197-203.
- High CXCL-16 Levels Correlate With Symptomatic Disease in Lung Transplant Recipients With Human Cytomegalovirus Replication in the Allograft. Weseslindtner L et al. Am J Transplant. 2014; 14: 2406-11.
- Prospective Analysis of Human Cytomegalovirus DNAemia and Specific CD8+ T-Cell Responses in Lung Transplant Recipients. Weseslindtner L et al. Am J Transplant. 2012; 12:2172-80.