Diabetes Mellitus; Diabetes, Gestational; Dyslipidemias; Endocrinology; Glucose Metabolism Disorders; Osteoporosis
My current research investigates the relationship between cholesterol-lowering drugs such as statins and the development of hormone-related diseases. Statins inhibit HMG-CoA reductase, the main enzyme in the synthesis of cholesterol. Cholesterol is the basic substance for the synthesis of vital hormones such as testosterone or oestrogen. I am therefore currently investigating whether there is a dose-dependent relationship between statins and osteoporosis.
Further research interests are:
- Endocrinology and metabolism
- Diabetes mellitus
- Gender Medicine
- Gestational diabetes
Techniques, methods & infrastructure
- Big data
- Prospective clinical studies
- Functional tests measuring insulin secretion, insulin sensitivity, beta-cell function and incretins
- Continuous glucose monitoring
- Magnetic resonance spectroscopy
- Intestinal microbiome
- Leutner, M et al, 2019. Diagnosis of osteoporosis in statin-treated patients is dose-dependent. Ann Rheum Dis. 2019 Dec;78(12):1706-1711.
- Leutner, M et al, 2019. A Sex-Specific Analysis of the Predictive Value of Troponin I and T in Patients With and Without Diabetes Mellitus After Successful Coronary Intervention. Front Endocrinol (Lausanne). 2019 Mar 1;10:105.
- Leutner, M et al, 2019. Glucagon-like peptide 1 (GLP-1) drives postprandial hyperinsulinemic hypoglycemia in pregnant women with a history of Roux-en-Y gastric bypass operation. Metabolism. 2019 Feb;91:10-17.
- Leutner, M et al, 2018. Pericardial Fat Relates to Disturbances of Glucose Metabolism in Women with the Polycystic Ovary Syndrome, but Not in Healthy Control Subjects. Int J Endocrinol. 2018 Aug 7;2018:5406128.
- Leutner, M et al, 2016. Clinical and metabolic characteristics of treated hyperlipidemic patients additionally affected by subclinical hyperglycemia. Lipids Health Dis. 2016 Jan 13;15:10.