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Detail

Martin Krssak
Mag. Dr. Martin KrssakAssociate Professor of Medical Physics

Department of Medicine III (Division of Endocrinology and Metabolism)
Position: Associate Professor

T +43 1 40400 37710
martin.krssak@meduniwien.ac.at

Further Information

Keywords

Diabetes Mellitus, Experimental; Magnetic Resonance Spectroscopy; Physiology

Research group(s)

  • Substrate Metabolism

Research interests

Non invasive assessment of ectopic lipid accumulation, glucose fluxes and ATP-handling in skeletal muscle, liver and myocardium by in vivo NMR spectroscopy.

Method development and integrative applications for the research of pathophysiology of diabetes mellitus and non-alcoholic fatty liver diseases as well as sports physiology.

Techniques, methods & infrastructure

In vivo multinuclear  - 1H, 13C, and 31P - magnetic resonance spectroscopy in human and animal disease models

Cooperatiion with Centre of Excellence -  High Field MR (Prof. Trattnig) and Preclinical Imaging Laboratory (Prof. Helbich), Department of Biomedical Imaging and Image guided Therapy (Radiodiagnostik und Nuklearmedizin).

Selected publications

  1. M. Krssak, K. Falk Petersen, A. Dresner, L. DiPietro, S. M. Vogel, D. L. Rothman, M. Roden, G. I. Shulman Intramyocellular Lipid Concentrations are Correlated with Insulin Sensitivity in Man: A 1H NMR Spectroscopy Study. Diabetologia 42: 113-116, 1999
  2. M. Krssak, A. Brehm, E. Bernroider, C. Anderwald, C. Dalla Man, P. Nowotny, C. Cobelli, G.W. Clilne, G.I. Shulman, W. Waldhäusl, M. Roden. Alteration in postprandial hepatic glycogen metabolism in type 2 diabetes mellitus. Diabetes 53(12): 3048-3056, 2004
  3. L. Valkovic, M. Gajdosik, S. Traussnigg, P. Wolf, M. Chmelik, W. Bogner, M. Krebs, M.Trauner, S. Trattnig, M. Krssak. Application of localized 31P MRS saturation transfer at 7T for measurement of ATP metabolism in the liver: reproducibility and first clinical application in patients with non-alcoholic fatty liver disease. Eur Radiol (2014) 24:1602,
  4. M. Gajdosik, G. Chadzynski, G. Hangel, V. Mlynarik, M. Chmelik, L. Valkovič, W. Bogner, R. Pohman, K. Scheffler, S. Trattnig, M. Krssak. Ultra-short TE STEAM and offline water signal subtraction improve quantification of lipids, choline-containing compounds and detection of fatty acid chains unsaturation in liver at 7 T. NMR Biomed. 2015 Oct;28(10):1283-93. doi: 10.1002/nbm.3382.
  5. M. Chmelik, L. Valkovič, P. Wolf, W. Bogner, M Gajdosik, S. Gruber, M. Krebs, S. Trattnig, and M. Krssak. Phosphatidylcholine contributes to in vivo 31P MRS signal from the human liver. Eur Radiol. 2015 Jan 11. [Epub ahead of print] DOI 10.1007/s00330-014-3578-y