Chemokine CXCL5; Chemokines; Neutrophils
Events promoting tumor progression and metastasis occur at early stages of malignant cancers and usually consist of tumor – stromal, tumor - lymph/blood vessel and tumor – immune system interactions. In cutaneous melanoma, lymph node metastasis is the first hallmark of advanced stage disease, thus meaning a worse clinical prognosis with mortality rates exceeding 50%. Identification of leading signaling networks controlling lymphogenic metastasis remains a major challenge. We aim to identify tumor- and stromal-derived factors that influence metastatic behavior and to dissect their signaling and functional properties with regard to enable early lymphogenic tumor spread.
Techniques, methods & infrastructure
Qualitative and quantitative methods in protein biochemistry and molecular biology, cell and tissue culture, transfection of cells, flow cytometry, histology and immuno-histochemistry, metastatic melanoma mouse models
- Ristl, R. et al., 2012. Description of a Putative Oligosaccharyl:S-Layer Protein Transferase from the Tyrosine <i>O</i>-Glycosylation System of <i>Paenibacillus alvei</i> CCM 2051<sup>T</sup> AiM, 02(04), pp.537-546. Available at: http://dx.doi.org/10.4236/aim.2012.24069.