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Detail

Agnes Forsthuber
Agnes Forsthuber, PhD

Department of Dermatology
Position: PHD Student

ORCID: 0000-0001-6396-0090
T +43 1 40400 73806
agnes.forsthuber@meduniwien.ac.at

Keywords

Chemokine CXCL5; Chemokines; Melanoma; Neutrophils

Research group(s)

Research interests

Events promoting tumor progression and metastasis occur at early stages of malignant cancers and usually consist of tumor – stromal, tumor - lymph/blood vessel and tumor – immune system interactions. In cutaneous melanoma, lymph node metastasis is the first hallmark of advanced stage disease, thus meaning a worse clinical prognosis with mortality rates exceeding 50%. Identification of leading signaling networks controlling lymphogenic metastasis remains a major challenge. We aim to identify tumor- and stromal-derived factors that influence metastatic behavior and to dissect their signaling and functional properties with regard to enable early lymphogenic tumor spread.

Techniques, methods & infrastructure

Metastatic mouse melanoma models, flow cytometry, qualitative and quantitative methods in protein biochemistry and molecular biology, cell and tissue culture, transfection of cells, histology and immuno-histochemistry

Selected publications

  1. Forsthuber, A. et al., 2018. CXCL5 as Regulator of Neutrophil Function in Cutaneous Melanoma. Journal of Investigative Dermatology. Available at: http://dx.doi.org/10.1016/j.jid.2018.07.006.
  2. Soler-Cardona, A. and Forsthuber, A. et al., 2018. CXCL5 Facilitates Melanoma Cell-Neutrophil Interaction and Lymph Node Metastasis. Journal of Investigative Dermatology, 138(7), pp.1627-1635. Available at: http://dx.doi.org/10.1016/j.jid.2018.01.035.
  3. Ristl, R. et al., 2012. Description of a Putative Oligosaccharyl:S-Layer Protein Transferase from the Tyrosine O-Glycosylation System of Paenibacillus alvei CCM 2051T. Adv Microbiol. 2012 Dec 1;2(4):537-546. Available at: http://dx.doi.org/10.4236/aim.2012.24069.