Detail

Keywords

Lymphoma, Non-Hodgkin; Sex-specific Differences

Research group(s)

• Vanura
  Head: Katrina Vanura
  Research Area: Our research encompasses various aspects of lymphoid malignancies - host and tumor genetics, environmental factors, sex specific differences, markers for prognosis and treatment response.
  Members:
  Katrina Vanura

Research interests

Lymphoid malignancies particularly of the B-cell type are among the most common malignancies in Western countries. They are also characterized by a male preponderance and a more benevolent disease course in women. We try to elucidate the bases of these sex-specific differences which not only seem to have an impact on the molecular characteristics of the malignant cells but also on clinical presentation and response to treatment.

Selected publications

1. Allain, E.P. et al., 2019. Inactivation of Prostaglandin E2 as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia. Frontiers in Oncology, 9. Available at: http://dx.doi.org/10.3389/fonc.2019.00606.
2. Allain, E.P. et al., 2018. Sex-dependent association of circulating sex steroids and pituitary hormones with treatment-free survival in chronic lymphocytic leukemia patients. Annals of Hematology, 97(9), pp.1649–1661. Available at: http://dx.doi.org/10.1007/s00277-018-3356-z.
3. Freund, P. et al., 2016. Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation G. Velasco, ed. PLOS ONE, 11(6), p.e0156693. Available at: http://dx.doi.org/10.1371/journal.pone.0156693.
4. Brunhofer-Bolzer, G. et al., 2015. SAR-Guided Development and Characterization of a Potent Antitumor Compound toward B-Cell Neoplasms with No Detectable Cytotoxicity toward Healthy Cells. Journal of Medicinal Chemistry, 58(3), pp.1244–1253. Available at: http://dx.doi.org/10.1021/jm501848m.
5. Porpaczy, E. et al., 2013. Lipoprotein lipase in chronic lymphocytic leukaemia – Strong biomarker with lack of functional significance. Leukemia Research, 37(6), pp.631–636. Available at: http://dx.doi.org/10.1016/j.leukres.2013.02.008.