Adrenal Glands; Bariatric Medicine; Endocrinology; Glucose Clamp Technique; Glucose Metabolism Disorders; Insulin Resistance; Magnetic Resonance Spectroscopy; Obesity, Morbid; Phenotype; Pituitary Diseases; Pituitary Function Tests; Thyroid Diseases
- Substrate Metabolism
During the recent years we have performed studies on glucose metabolism in normal volunteers and diabetic subjects using NMR spectroscopy (non-invasive determination of glycogen concentrations in skeletal muscle and liver, muscular glucose-6-phosphate, and intracellular lipids). Our group also applies various tracer techniques and biopsies of skeletal muscle in combination with hyperinsulinemic- and pancreatic-clamp tests to determine rates of glucose turnover, gluconeogenesis, and molecular mechanisms insulin resistance. We am especially interested in elucidating the mechanisms of nutrient induced insulin resistance in humans. A major focus of my research work was the pathogenesis of vascular and myocardial disease associated with the insulin resistance syndrome and type 2 diabetes.
Techniques, methods & infrastructure
- Metabolic NMR spectroscopy in vivo
- Comprehensive metabolic phenotyping (Clamp Studies, Biopsies)