Department of Otorhinolaryngology (Division of General Otorhinolaryngology)
Position: Doctor-in-training
ORCID: 0000-0002-3475-763X
anselm.gadenstaetter@meduniwien.ac.at
Keywords
Audiometry; Cochlear Implantation; Drug Delivery Systems; Evoked Potentials, Auditory; Hearing Loss; Neurotology; Skull Base Neoplasms; Translational Medical Research
Research group(s)
- Christian Doppler Lab for Inner Ear Research
Head: Christoph Arnoldner
Research Area: This CD laboratory investigates the underlying mechanisms of inner ear diseases and researches various therapeutic approaches for the treatment of hearing loss. The high prevalence of hearing loss worldwide and the expected increase in hearing loss require innovative research strategies to improve patient care.
Members:
Research interests
My research within the Christian Doppler Lab for Inner Ear Research mainly focuses on translational research with the aim to help better understand and treat diseases of the inner ear. By performing experiments in small and large animal models, I investigate cochlear implantation trauma, novel pharmacotherapies for inner ear disorders, and cochlear drug delivery strategies. Besides my lab work, I study clinical outcomes following cochlear implantation and vestibular schwannoma surgery.
Selected publications
- Gadenstaetter, A.J. et al. (2023) ‘Functional Outcome After Simultaneous Vestibular Schwannoma Resection and Cochlear Implantation With Intraoperative Cochlear Nerve Monitoring’, Otolaryngology–Head and Neck Surgery, 168(6), pp. 1502–1510. Available at: https://doi.org/10.1002/ohn.233.
- Gadenstaetter, A.J. et al. (2024) ‘Prestin in Human Perilymph, Cerebrospinal Fluid, and Blood as a Biomarker for Hearing Loss’, Otolaryngology–Head and Neck Surgery, 171(6), pp. 1825–1833. Available at: https://doi.org/10.1002/ohn.895.
- Yildiz, E. et al. (2023) ‘Investigation of inner ear drug delivery with a cochlear catheter in piglets as a representative model for human cochlear pharmacokinetics’, Frontiers in Pharmacology, 14:1062379. Available at: https://doi.org/10.3389/fphar.2023.1062379.
- Gadenstaetter, A.J., Krumpoeck, P.E. and Landegger, L.D. (2024) ‘Inner Ear Gene Therapy: An Overview from Bench to Bedside’, Molecular Diagnosis & Therapy, 29(2), pp. 161–181. Available at: https://doi.org/10.1007/s40291-024-00759-1.
- Gadenstaetter, A.J. et al. (2022) ‘Intranasal application of adeno-associated viruses: a systematic review’, Translational Research, 248, pp. 87–110. Available at: https://doi.org/10.1016/j.trsl.2022.05.002.