Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Research Associate (Postdoc)
ORCID: 0000-0002-7203-7174
T +43 1 40400 20340
cecile.philippe@meduniwien.ac.at
Keywords
Drug Evaluation, Preclinical; Molecular Imaging; Positron-Emission Tomography; Radioactive Tracers
Research group(s)
Research interests
Biomedical Imaging and Tracer Development
My main area of research is the preclinical development and evaluation of radiopharmaceuticals with focus on energy metabolism and immunology. Thereby, I am focusing on following targets:
- Melanin Concentrating Hormone Receptor 1 (MCHR1)
- Glucose and fatty acid metabolism
- ED-B Fibronectin
- T-cells
- Fibroblast Activation Protein (FAP)
- Folate Receptor alpha (FRa)
My expertise rages from radiochemistry to non-invasive molecular imaging and ex vivo analyses.
Techniques, methods & infrastructure
Techniques:
- Radiosynthesis
- Binding-studies (cell culture)
- Metabolism
- Blood-brain-barrier penetration
- Autoradiography
- Immunhistochemistry
- Small animal PET/CT/MRI
- Biodistribution
- Genotyping
- PCR
- MACS
- FACS
Access to the Preclinical Imaging Laboratory (FELASA certificate).
Selected publications
- Philippe, C. et al., 2018. SNAPshots of the MCHR1: a Comparison Between the PET-Tracers [18F]FE@SNAP and [11C]SNAP-7941. Molecular Imaging and Biology. Available at: http://dx.doi.org/10.1007/s11307-018-1212-0.
- Zeilinger, M. et al., 2017. In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [11C]SNAP-7941 and [18F]FE@SNAP reveal specific uptake in the ventricular system. Scientific Reports, 7(1). Available at: http://dx.doi.org/10.1038/s41598-017-08684-6.
- Philippe, C. et al., 2014. Comparative autoradiographic in vitro investigation of melanin concentrating hormone receptor 1 ligands in the central nervous system. European Journal of Pharmacology, 735, pp.177-183. Available at: http://dx.doi.org/10.1016/j.ejphar.2014.04.020.
- Philippe, C., Klebermass, E.M., et al., 2021. Discovery of melanin-concentrating hormone receptor 1 in brown adipose tissue. Ann N Y Acad Sci. 1494:70-86
- Philippe, C. et al., 2015. Parameter evaluation and fully-automated radiosynthesis of [11C]harmine for imaging of MAO-A for clinical trials. Applied Radiation and Isotopes, 97, pp.182-187. Available at: http://dx.doi.org/10.1016/j.apradiso.2015.01.002.