Animal models; Artificial Organs; Bioengineering; Biomedical Engineering; Blood; Cardiovascular; Cardiovascular System; Heart; Heart Failure
- CARE - Cardiovascular Research and Engineering
- Christian Doppler Lab for Mechanical Circulatory Support
Head: Marcus Granegger
My research focuses on device-based treatment options for unmet medical needs in cardiovascular medicine. On the one hand our group develops innovative systems for mechanical circulatory support, one the other hand we optimize the patient-device interaction to promote preservation or even recovery of cardiovascular function.
Techniques, methods & infrastructure
Our team covers the entire R&D pipeline for complex medical devices, from in-silico methods (CAD, CFD, lumped parameter models, virtual fitting), in-vitro experiments (hybrid test benches, animal/human blood experiments), ex-vivo approaches (isolated beating heart model) to in-vivo animal models (acute and chronic large animal experiments) and clinical studies.
- Christian Doppler Lab for Mechanical Circulatory Support (2023)
Source of Funding: CDG (Christian Doppler Research Association), CD Laboratory
- Linking cardiac biomechanics to reverse remodeling (2023)
Source of Funding: FWF (Austrian Science Fund), Standalone project
- Optimized Hydrodynamic Flow Behaviour by Selective Surface Structured of Ceramic 3D Printed Rotodynamic Blood Pumps. (2022)
Source of Funding: FFG (Austrian Research Promotion Agency), Produktion der Zukunft
- Granegger, M. et al. (2022) ‘Comparison of device-based therapy options for heart failure with preserved ejection fraction: a simulation study’, Scientific Reports, 12(1). Available at: http://dx.doi.org/10.1038/s41598-022-09637-4.
- Escher, A. et al. (2022) ‘Hemolytic Footprint of Rotodynamic Blood Pumps’, IEEE Transactions on Biomedical Engineering, pp. 1–1. Available at: http://dx.doi.org/10.1109/tbme.2022.3146135.
- Escher, A. et al. (2022) ‘A Cavopulmonary Assist Device for Long-Term Therapy of Fontan Patients’, Seminars in Thoracic and Cardiovascular Surgery, 34(1), pp. 238–248. Available at: http://dx.doi.org/10.1053/j.semtcvs.2021.06.016.
- Granegger, M. et al. (2019) ‘Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps’, Scientific Reports, 9(1). Available at: http://dx.doi.org/10.1038/s41598-019-56344-8.
- Granegger, M. et al. (2020) ‘Blood trauma potential of the HeartWare Ventricular Assist Device in pediatric patients’, The Journal of Thoracic and Cardiovascular Surgery, 159(4), pp. 1519-1527.e1. Available at: http://dx.doi.org/10.1016/j.jtcvs.2019.06.084.