Artificial Organs; Assisted Circulation; Biomedical Engineering; Blood; Cardiovascular
- CARE - Cardiovascular Research and Engineering
- Christian Doppler Lab for Mechanical Circulatory Support
Head: Marcus Granegger
The potential of mechanical circulatory support therapy has not yet been fully exploited due to adverse events caused by limited hemocompatibility of the devices. My main research focus is on rotodynamic blood pump design and the effects of pump flow on hemocompatibility - both in studying current clinically used cardiac assist devices and developing new devices for previously unaddressed patient populations, such as the Fontan population.
Techniques, methods & infrastructure
To understand the connection between pump design, flow and hemocompatibility related adverse events, I employ both in-silico (e.g. Computational Fluid Dynamics simulation) as well as in-vitro methods (e.g. performance testing in flow loop, blood testing).
- Escher, A. et al. (2023) ‘In-Vitro Flow Validation of Third-Generation Ventricular Assist Devices: Feasibility and Challenges’, ASAIO Journal [Preprint]. Available at: http://dx.doi.org/10.1097/mat.0000000000002009.
- Granegger, M. et al. (2020) ‘Blood trauma potential of the HeartWare Ventricular Assist Device in pediatric patients’, The Journal of Thoracic and Cardiovascular Surgery, 159(4), pp. 1519-1527.e1. Available at: http://dx.doi.org/10.1016/j.jtcvs.2019.06.084.
- Granegger, M. et al. (2019) ‘A long-term mechanical cavopulmonary support device for patients with Fontan circulation’, Medical Engineering & Physics, 70, pp. 9–18. Available at: http://dx.doi.org/10.1016/j.medengphy.2019.06.017.
- Thamsen, B. et al. (2020) ‘Assessment of the Flow Field in the HeartMate 3 Using Three-Dimensional Particle Tracking Velocimetry and Comparison to Computational Fluid Dynamics’, ASAIO Journal, 66(2), pp. 173–182. Available at: http://dx.doi.org/10.1097/mat.0000000000000987.
- Thamsen, B. et al. (2018) ‘Investigation of the Axial Gap Clearance in a Hydrodynamic-Passive Magnetically Levitated Rotary Blood Pump Using X-Ray Radiography’, Artificial Organs, 42(5), pp. 510–515. Available at: http://dx.doi.org/10.1111/aor.13074.