Aneurysm, Ruptured; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Biomarkers, Pharmacological; Cardiovascular Abnormalities; Cardiovascular Diseases; Cardiovascular System; Carotid Artery Diseases; General Surgery; Glomerular Filtration Rate; Kidney Failure, Chronic; Kidney Function Tests; Molecular Biology; Monocytes; Neutrophils; Randomized Controlled Trial
- Arge Brostjan
Research Area: Vascular Disease; interplay of endothelial cells, platelets and leukocytes in pro-inflammatory activation, coagulation and angiogenesis
- Vienna Vascular Surgery Research Laboratories
My main research focus is to investigate biomarkers and inflammatory components in cardiovascular and associated diseases, especially focused on translational research regarding neutrophils and neutrophil extracellular traps (NETs) in abdominal aortic aneurysms (AAAs).
We perform different mouse models of AAA and the research is designed to elucidate molecular mechanisms of cardiovascular disease underlying different aspects of pathology and to develop novel therapeutic approaches.
In addition, I am involved in randomized clinical trials and biobanking at the Department of Surgery - Division of Vascular Surgery at the Medical University of Vienna, Vienna General Hospital.
- Finlandia Prize of the Association of International Vascular Surgeons 2023
- Helmut Sinzinger Award of the Gesellschaft der Ärzte in Wien (College of Physicians in Vienna) 2023, 3rd Prize Winner
- Award Winner of the Hans and Blanca Moser-Foundation for Cardiovascular Research 2022
- Best Young Investigator Award of the European and Austrian Society for Surgical Research 2020
- Award Winner of the Austrian Society of Surgery 2020
- PhD Student of the Month Award - Medical University of Vienna
- Member of the International Society of Surgery
- Member of the Austrian Society of Vascular Surgery
- Member of the German Society of Vascular Surgery
- Member of the Austrian Society of Surgical Research
- Member of the Austrian Society of Surgery
- Klopf, J. et al. (2023) ‘MetAAA trial patients show superior quality of life compared to patients under regular surveillance for small AAA – A single-center retrospective cohort study’, International Journal of Surgery, Publish Ahead of Print. Available at: http://dx.doi.org/10.1097/js9.0000000000000343.
- Klopf, J. et al. (2022) ‘The prognostic impact of vascular calcification on abdominal aortic aneurysm progression’, Journal of Vascular Surgery, 75(6), pp. 1926–1934. Available at: http://dx.doi.org/10.1016/j.jvs.2021.11.062.
- Klopf, J. et al. (2021) ‘Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease’, International Journal of Molecular Sciences, 22(2), p. 559. Available at: http://dx.doi.org/10.3390/ijms22020559.
- Klopf, J. et al. (2020) ‘Bisherige Strategien und zukünftige Perspektive zur Reduzierung der Wachstumsraten bei abdominellen Aortenaneurysmen’, Gefässchirurgie, 25(6), pp. 446–449. Available at: http://dx.doi.org/10.1007/s00772-020-00665-w.
- Eilenberg, W. et al. (2021) ‘Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms’, Translational Research, 233, pp. 32–46. Available at: http://dx.doi.org/10.1016/j.trsl.2021.02.003.