Detail

Keywords

Epithelial-Mesenchymal Transition; Melanoma

Research group(s)

• Tissue Homeostasis Group
  Head: Karin Pfisterer
  Members:
  Parvaneh Balsini
  Pauline Weinzettl
  Karin Pfisterer

Research interests

My research focusses on analyzing key characteristics and processes of the epithelial-mesenchymal transition in melanoma cells. I am investigating the migratory behavior of poorly and highly metastatic cells to compare the differences and thereby identify underlying cellular processes of cell migration.

Techniques, methods & infrastructure

• Cell and tissue culture
• Confocal microscopy
• Life cell imaging
• 3D collagen matrix engineering

Selected publications

1. Al Awabdh, S. et al. (2021) ‘Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons’, The Journal of Neuroscience, 42(2), pp. 166–182. Available at: http://dx.doi.org/10.1523/jneurosci.2926-20.2021.
2. Pfisterer, K. et al. (2023) ‘Non-IgE-reactive allergen peptides deteriorate the skin barrier in house dust mite-sensitized atopic dermatitis patients’, Frontiers in Cell and Developmental Biology, 11. Available at: https://doi.org/10.3389/fcell.2023.1240289.
3. Balsini, P. et al. (2024) ‘Stiffness-dependent LOX regulation via HIF-1 drives extracellular matrix modifications in psoriasis’. Available at: https://doi.org/10.1101/2024.05.14.594058.