Center for Anatomy and Cell Biology (Division of Anatomy), Department of Otorhinolaryngology (Division of General Otorhinolaryngology)
Position: Doctor-in-training
ORCID: 0000-0003-4139-7940
T +43 1 40160-37758
sam.kandathil@meduniwien.ac.at
Keywords
Anatomic Variation; Anatomy; Autophagy; Chemoradiotherapy; Chemotherapy resistance; Free Tissue Flaps; Head and Neck Neoplasms; Mandibular Reconstruction; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microsurgery; Neck Dissection; Oncology; Organoids; Primary Cell Culture; Receptors, Interleukin-6; Reconstructive Surgical Procedures; Spheroids, Cellular; Translational Medical Research
Research group(s)
- Hirtler Lab
Head: Lena Hirtler
Research Area: The members of this research group address a wide range of anatomical and clinical-morphological questions. Starting from classical anatomical and histological evaluations to clinical applications, e.g. minimally invasive surgery and imaging procedures, research questions are processed by the use of state-of-the-art techniques. Apart from stand-alone projects, the group is characterized by collaborations with a variety of partners to tackle currently relevant issues in clinical practice.
Members: - Basic Oncology Research in Head and Neck Cancer
Members:
Research interests
- Translational research
- patient-derived head and neck sqamous cell carcinoma (HNSCC) culture (cultivating and engineering HNSCC-organoids and spheroids)
- patient-derived xenografts (PDX)
- organoid-derived grafts (ODX)
- 4-NQO mouse model
- Tumor microenvironment (TME)
- influence of TME on cancer chemo- and radioresistance
- Autophagy
- role of autophagy in cancer development and response to chemo- and radiotherapy
- Extracellular matrix (ECM)
- creating scaffolds and hydrogels derived from animals and humans for in vitro applications
- influence of ECM on HNSCC tumor progression and invasion
- Thin section histology
- currently establishing Methylmethacrylat-based histology to analyse implant-tissue-interactions