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Sylvia Knapp
Prof. Dr. Sylvia Knapp, PhDHead of Infection Biology Lab

Department of Medicine I
Position: Professor

ORCID: 0000-0001-9016-5244
T +43 1 40400 51390

Further Information


Immunity, Innate; Inflammation; Macrophages; Pneumonia; Sepsis

Research group(s)

Research interests

We focus on a better understanding of the modulation of innate immune responses during clinically relevant bacterial/viral infections and inflammatory diseases. The main focus is placed on the biological function and plasticity of macrophages in tissues infected by pathogens or injured in the course of inflammation. The long term objective pertains to an improved assessment of the regulation of inflammatory processes in order to identify novel therapeutic and diagnostic targets. 


Selected publications

  1. Starkl, P. et al., 2020. IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcus aureus. Immunity, 53(4), pp.793–804.e9. Available at:
  2. Cohen, M. et al., 2018. Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting. Cell, 175(4), pp.1031-1044.e18. Available at:
  3. Saluzzo, S. et al., 2017. First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment. Cell Reports, 18(8), pp.1893-1905. Available at:
  4. Martins, R. et al., 2016. Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. Nature Immunology, 17(12), pp.1361-1372. Available at:
  5. Warszawska, J.M. et al., 2013. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. Journal of Clinical Investigation, 123(8), pp.3363-3372. Available at: