Detail

Keywords

Fatty Liver; Liver Cirrhosis; Malnutrition

Research group(s)

• Metabolic and Bariatric Surgery
  Members:
  Julia Jedamzik
  Lisa Gensthaler
  Daniel Moritz Felsenreich
  Magdalena Mairinger
  Jakob Eichelter
  Christoph Bichler
  Felix Langer
  Christine Mölzer
• AG Prager
  Head:
  Research Area: Metabolic-bariatric surgery
  Members:
  Christine Mölzer

Research interests

- Energy metabolism and obesity in the context of metabolic-bariatric surgery (Energiestoffwechsel und Adipositas im Kontext metabolisch-bariatrischer Chirurgie)

- Immuno-metabolism and aspects of molecular nutrition (Immuno-Metabolismus und Aspekte der molekularen Ernährung)

- Mechanisms of liver fibrosis in the context of metabolic-associated fatty liver disease/MAFLD (Mechanismen der Leberfibrose im Zusammenhang mit metabolisch-assoziierter Fettleber/MAFLD)

Techniques, methods & infrastructure

We are interested in exploring molecular and immune pathways that are involved in (de novo) liver fibrosis. To this end we engage in in vitro (cell cultures), in vivo (rat model), and ex vivo (human biobanking) research, using a broad spectrum of wet-lab methodology such as flow cytometry, qPCR, western blot, plate assays, electrophysiology (Ussing), and collaborate with (in-house) core facilities to explore targeted and non-targeted aspects of the mammalian metabolome. We are particularly interested in the folate pool and functional folate deficiency.

Selected publications

1. Liu, Y.-H. et al. (2020) ‘Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis’, Frontiers in Immunology, 11. Available at: https://doi.org/10.3389/fimmu.2020.02071.
2. Mölzer, C. et al. (2019) ‘TGF‐β1‐activated type 2 dendritic cells promote wound healing and induce fibroblasts to express tenascin c following corneal full‐thickness hydrogel transplantation’, Journal of Tissue Engineering and Regenerative Medicine, 13(9), pp. 1507–1517. Available at: https://doi.org/10.1002/term.2853.
3. Mölzer, C. et al. (2023) ‘Colitis in a transgenic mouse model of autoimmune uveitis may be induced by neoantigen presentation in the bowel’, Scientific Reports, 13(1). Available at: https://doi.org/10.1038/s41598-022-27018-9.
4. Wagner, K.-H. et al. (2021) ‘Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies’, Antioxidants, 10(9), p. 1474. Available at: https://doi.org/10.3390/antiox10091474.
5. Mairinger, M. et al. (2025) ‘Progression of liver fibrosis after metabolic bariatric surgery in a MASLD rat model’, Clinical Nutrition, 52, pp. 225–233. Available at: https://doi.org/10.1016/j.clnu.2025.07.019.