Kidney; Molecular Imaging; Pharmacokinetics
My main research focus is kinetic modeling, i.e. the quantification of radiopharmaceutical processes in the body on the basis of imaging techniques. In particular, I am interested in the renal processes of FDG, a routine tracer in nuclear medicine for PET examinations.
Techniques, methods & infrastructure
PET/CT and PET/MRI are used predominantly with FDG. Several human studies with healthy subjects, diabetes patients, etc as well as animal studies are performed in comparison with standard methods. Software is developed to evaluate the tracer concentration over time and to create kinetic models.
- Geist, B.K. et al., 2015. WWSSF - a worldwide study on radioisotopic renal split function. Nuclear Medicine Communications, 36(12), pp.1233-1238. Available at: http://dx.doi.org/10.1097/MNM.0000000000000380.
- Geist, B.K., Diemling, M. & Staudenherz, A., 2016. Glomerular Filtration Rate and Error Calculation Based on the Slope-Intercept Method with Chromium-51 Ethylenediaminetetraacetic Acid via a New Clinical Software: GFRcalc. Medical Principles and Practice, 25(4), pp.368-373. Available at: http://dx.doi.org/10.1159/000445028.
- Geist, B.K. et al., 2018. Assessing the kidney function parameters glomerular filtration rate and effective renal plasma flow with dynamic FDG-PET/MRI in healthy subjects. EJNMMI Research, 8(1). Available at: http://dx.doi.org/10.1186/s13550-018-0389-1.