Detail

Keywords

Optical Imaging; Physics; Tomography, Optical Coherence

Research group(s)

• Baumann Lab
  Head: Bernhard Baumann
  Research Area: Develop multi-functional imaging techniques based in OCT for the preclinical diagnostic of Alzheimer's disease.
  Members:
  Pablo Eugui
  Marco Augustin
  Conrad Merkle
  Bernhard Baumann
  Danielle J. Harper
  Antonia Lichtenegger

Research interests

Optical methods enable rapid, noninvasive, and three-dimensional imaging with micrometer scale resolution. My research interests are the development of new optical methods for biomedical imaging – in particular optical coherence tomography (OCT) – and their application for improved diagnostics of diseases in both clinical and preclinical research.

Techniques, methods & infrastructure

• Optical imaging setups for retinal and microscopic imaging
• Image processing and analysis
• Longitudinal studies in biomedical research settings

Grants

• OPTIMALZ - Optical imaging of ocular pathology in Alzheimer’s disease (2015)
  Source of Funding: EU, ERC-2014-STG
  Principal Investigator
• Preclinical imaging of the rodent eye with multi-functional optical coherence tomography (2013)
  Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
  Principal Investigator

Selected publications

1. Harper, D.J. et al., 2020. Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography. Neurophotonics, 7(01), p.1. Available at: http://dx.doi.org/10.1117/1.NPh.7.1.015006.
2. Merkle, C. et al., 2020. Indocyanine green provides absorption and spectral contrast for optical coherence tomography at 840 nm in vivo. Optics Letters. Available at: http://dx.doi.org/10.1364/OL.380051.
3. Baumann, B. et al., 2019. Signal averaging improves signal-to-noise in OCT images: But which approach works best, and when? Biomedical Optics Express, 10(11), p.5755. Available at: http://dx.doi.org/10.1364/BOE.10.005755.
4. Eugui, P. et al., 2019. Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography. Optics Letters, 44(16), p.4040. Available at: http://dx.doi.org/10.1364/OL.44.004040.
5. Lichtenegger, A. et al., 2019. Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging. Journal of Biomedical Optics, 24(06), p.1. Available at: http://dx.doi.org/10.1117/1.JBO.24.6.066010.