Detail

Keywords

Optical Imaging; Physics; Tomography, Optical Coherence

Research group(s)

• Baumann & Merkle Group
  Head: Bernhard Baumann
  Research Area: Development of multi-functional imaging techniques based on OCT for studying eye and brain diseases.
  Members:
  Conrad Merkle
  Bernhard Baumann
  Yash Patel
  Sybren Worm
  Georg Ladurner
  Maria Varaka

Research interests

Optical methods enable rapid, noninvasive, and three-dimensional imaging with micrometer scale resolution. My research interests are the development of new optical methods for biomedical imaging – in particular optical coherence tomography (OCT) – and their application for improved diagnostics of diseases in both clinical and preclinical research.

Techniques, methods & infrastructure

• Optical imaging setups for retinal and microscopic imaging
• Image processing and analysis
• Longitudinal studies in biomedical research settings

Grants

• Deciphering nano-scale tissue motion (2022)
  Source of Funding: FWF (Austrian Science Fund), International Projects
  Principal Investigator
• OPTIMEYEZ - Optical imaging platform for high-throughput longitudinal studies of the eye in disease models (2022)
  Source of Funding: EU, ERC Proof of Concept
  Principal Investigator
• OPTIMALZ - Optical imaging of ocular pathology in Alzheimer’s disease (2015)
  Source of Funding: EU, ERC-2014-STG
  Principal Investigator
• Preclinical imaging of the rodent eye with multi-functional optical coherence tomography (2013)
  Source of Funding: FWF (Austrian Science Fund), Stand-Alone Projects
  Principal Investigator

Selected publications

1. Baumann, B. and Woehrer, A. (2023) ‘Polarization-insensitive optical coherence tomography based on partly depolarized light’, Optics Letters [Preprint]. Available at: http://dx.doi.org/10.1364/ol.488143.
2. Merkle, C.W. et al. (2022) ‘Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1−/− Mice Using Intensity, Polarization, and Spectroscopic OCT’, Translational Vision Science & Technology, 11(10), p. 28. Available at: http://dx.doi.org/10.1167/tvst.11.10.28.
3. Baumann, B. et al. (2022) ‘Pulsatile tissue deformation dynamics of the murine retina and choroid mapped by 4D optical coherence tomography’, Biomedical Optics Express, 13(2), p. 647. Available at: http://dx.doi.org/10.1364/boe.445093.
4. Harper, D.J. et al. (2020) ‘Retinal analysis of a mouse model of Alzheimer’s disease with multicontrast optical coherence tomography’, Neurophotonics, 7(01), p. 1. Available at: http://dx.doi.org/10.1117/1.nph.7.1.015006.
5. Eugui, P. et al. (2019) ‘Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography’, Optics Letters, 44(16), p. 4040. Available at: http://dx.doi.org/10.1364/ol.44.004040.