Ap.Prof. Dietmar Herndler-BrandstetterPrincipal Investigator
Center for Cancer Research, Comprehensive Cancer Center
Position: Associate Professor
ORCID: 0000-0003-0987-0208
T +43 1 40160 - 57577
dietmar.herndler-brandstetter@meduniwien.ac.at
Keywords
Colorectal Neoplasms; Immune System; Immunotherapy; Tumor Microenvironment
Research interests
- Humanized mouse models for translational cancer research and immunotherapy
- Stromal regulation of immune cell development and anti-tumor immunity
Techniques, methods & infrastructure
- Humanized mouse models (MISTRG-6)
- Patient-derived tumor xenograft (PDX) models
- Cancer immunotherapies (myeloid cells, T cells)
- Spectral flow cytometry
- Spatial profiling
Grants
- Functional heterogeneity of mesenchymal stromal cells (2024)
Source of Funding: FWF (Austrian Science Fund), Principal Investigator Project
Principal Investigator - Innate immune reprogramming to overcome therapy resistance in high-risk colorectal cancer (2021)
Source of Funding: WWTF (Vienna Science and Technology Fund), Life Sciences / Precision Medicine
Coordinator of the collaborative project
Selected publications
- Stecher, C. et al. (2025) ‘Heterogeneity of IL-15-expressing mesenchymal stromal cells controls natural killer cell development and immune cell homeostasis’, Nature Communications, 16(1). Available at: https://doi.org/10.1038/s41467-025-61231-0.
- Herndler-Brandstetter, D. et al. (2018) ‘KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity’, Immunity, 48(4), pp. 716-729.e8. Available at: https://doi.org/10.1016/j.immuni.2018.03.015.
- Ring, N.G. et al. (2017) ‘Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity’, Proceedings of the National Academy of Sciences, 114(49). Available at: https://doi.org/10.1073/pnas.1710877114.
- Frank, M. et al. (2026) ‘Spatial organization of stromal subtypes stratifies colorectal cancer patients and predicts clinical outcomes’, Cancer Letters, 639, p. 218228. Available at: https://doi.org/10.1016/j.canlet.2025.218228.
- Chen, A. et al. (2025) ‘Comparison of NSG-Quad and MISTRG-6 humanized mice for modeling circulating and tumor-infiltrating human myeloid cells’, Molecular Therapy Methods & Clinical Development, 33(2), p. 101487. Available at: https://doi.org/10.1016/j.omtm.2025.101487.