Creativity; Functional Magnetic Resonance; Functional Neuroimaging; Gyrus Cinguli; Magnetic Resonance Imaging; Neurosciences; Nucleus Accumbens; Prefrontal Cortex; Transcranial Magnetic Stimulation
My main research focus is online concurrent TMS/fMRI. Different state of the art setups allow me to employ a systematic multi-modal investigation on local and remote TMS evoked brain activity changes, as measured by fMRI, to evaluate efficacy of existing stimulation paradigms and allow for optimisation of stimulation and imaging parameters.
Precision medicine approach to brainstimulation
Repetitive TMS over the left DLPFC has further shown potential in the treatment of depression but many patients do not respond to current state-of-the-science applications. Based on a neuronavigated concurrent TMS/fMRI setup, we demonstrate clinical target engagement during brain stimulation. This allows to set individualized parameters (such as dose, frequency) and monitor successful stimulation.
Techniques, methods & infrastructure
TMS allows for systematic modulation of the excitability of well-defined brain regions, this method is particularly suited to investigate and establish causal relationships between the modulation of neuronal activity and following changes in cerebral function and overt behavior.
Simultanous fMRI using inhouse developed seven channel receive magnetic resonance coil that is placed between the skull and the TMS coil. This allows to obtain fMRI data from the site of stimulation with unprecedented sensitivity.
- Tik, M. et al., 2017. Towards understanding rTMS mechanism of action: Stimulation of the DLPFC causes network-specific increase in functional connectivity. NeuroImage, 162, pp.289–296. Available at: http://dx.doi.org/10.1016/j.neuroimage.2017.09.022.
- Tik, M. et al., 2018. Ultra-high-field fMRI insights on insight: Neural correlates of the Aha!-moment. Human Brain Mapping, 39(8), pp.3241–3252. Available at: http://dx.doi.org/10.1002/hbm.24073.
- Tik, M. et al., 2017. Mapping TMS local and remote immediate effects by concurrent TMS/fMRI using a dedicated high-sensitivity coil array. Brain Stimulation, 10(2), pp.489–491. Available at: http://dx.doi.org/10.1016/j.brs.2017.01.432.
- Tik, M. et al., 2019. Individualizing Brainstimulation through concurrent TMS/fMRI. Brain Stimulation, 12(2), pp.425–427. Available at: http://dx.doi.org/10.1016/j.brs.2018.12.381.
- Tik, M. et al., 2019. Remission from depression and tms over left DLPFC share the same network connectivity changes. Brain Stimulation, 12(2), pp.435–436. Available at: http://dx.doi.org/10.1016/j.brs.2018.12.413.