Position: Research Assistant
maximilian.weissengruber@meduniwien.ac.at
Keywords
Drug Evaluation, Preclinical; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals
Research group(s)
- Experimental Nuclear Medicine
Head: Cécile Philippe
Research Area: The research group "Experimental Nuclear Medicine" focuses on the preclinical development and assessment of radiopharmaceuticals, with a particular emphasis on altered energy metabolism in aging, stress, disease and immune-oncology.
Members:
Research interests
My main research focus is the development of 18F radiotracers (e.g. 18F-FAC, 18F-CFA, 18F-FTHA) for preclinical studies utilizing different synthesis modules and the concomitant purification and analysis of said compounds. These tracers allow the non-invasive visualization of distinct metabolic and immune pathways in vivo. For example, 18F-FTHA is used to assess long-chain fatty acid uptake and utilization, while nucleoside analogues such as 18F-FAC enable imaging of immune cell proliferation via the deoxyribonucleoside salvage pathway.
Techniques, methods & infrastructure
- Radiosynthesizers/Synthesis Modules: ELIXYS, Synthra
- Synthetic/Preparative Chemistry
- Analytical Chemistry: HPLC-UV/RAD, GC-MS, TLC, etc.