Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Associate Professor
ORCID: 0000-0002-7203-7174
T +43 1 40400 55330
cecile.philippe@meduniwien.ac.at
Keywords
Drug Evaluation, Preclinical; Energy Metabolism; Molecular Imaging; Positron-Emission Tomography; Radioactive Tracers
Research group(s)
- Experimental Nuclear Medicine
Head: Cécile Philippe
Research Area: The research group "Experimental Nuclear Medicine" focuses on the preclinical development and assessment of radiopharmaceuticals, with a particular emphasis on altered energy metabolism in aging, stress, disease and immune-oncology.
Members: - Joint Medicinal Applied Radiochemistry Facility
Head: Markus Mitterhauser
Research Area: The newly founded Joint Applied Medicinal Radiochemistry Facility of the University of Vienna and the Medical University of Vienna connects researchers from different disciplines of the University of Vienna and the Medical University Vienna ranging from basic science to clinical applications.
Members:
Research interests
Biomedical Imaging and Tracer Development
My main area of research is the preclinical development and evaluation of radiopharmaceuticals with focus on energy metabolism and immunology. Thereby, I am focusing on following targets:
- Melanin Concentrating Hormone Receptor 1 (MCHR1)
- Glucose and fatty acid metabolism
- ED-B Fibronectin
- T-cells
- Fibroblast Activation Protein (FAP)
My expertise ranges from radiochemistry to non-invasive molecular imaging and ex vivo analyses.
Techniques, methods & infrastructure
Techniques:
- Radiosynthesis
- Binding-studies (cell culture)
- Metabolism
- Blood-brain-barrier penetration
- Autoradiography
- Immunhistochemistry
- Small animal PET/CT/MRI
- Biodistribution
- MACS
- FACS (RadioFlow)
Access to the Preclinical Imaging Laboratory (FELASA certificate).
Selected publications
- Vraka, C. et al. (2025) ‘RadioFlow Cytometry Reveals That [18F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level’, Journal of Nuclear Medicine, 66(2), pp. 215–222. Available at: https://doi.org/10.2967/jnumed.124.268799.
- Philippe, C. et al. (2021) ‘Discovery of melanin‐concentrating hormone receptor 1 in brown adipose tissue’, Annals of the New York Academy of Sciences, 1494(1), pp. 70–86. Available at: https://doi.org/10.1111/nyas.14563.
- Ustsinau, U. et al. (2023) ‘Novel approach using [18F]FTHA-PET and de novo synthesized VLDL for assessment of FFA metabolism in a rat model of diet induced NAFLD’, Clinical Nutrition, 42(10), pp. 1839–1848. Available at: https://doi.org/10.1016/j.clnu.2023.08.001.
- Pencik, J. et al. (2023) ‘STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway’, Molecular Cancer, 22(1). Available at: https://doi.org/10.1186/s12943-023-01825-8.
- Philippe, C. et al. (2018) ‘SNAPshots of the MCHR1: a Comparison Between the PET-Tracers [18F]FE@SNAP and [11C]SNAP-7941’, Molecular Imaging and Biology, 21(2), pp. 257–268. Available at: https://doi.org/10.1007/s11307-018-1212-0.