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Sam Augustine Kandathil
Sam Augustine Kandathil, M.D.

Department of Otorhinolaryngology (Clinical Division of General Otorhinolaryngology)
Position: Doctor-in-training

ORCID: 0000-0003-4139-7940
T +43 1 40400-33300
sam.kandathil@meduniwien.ac.at

Keywords

Anatomic Variation; Anatomy; Autophagy; Chemoradiotherapy; Chemotherapy resistance; Free Tissue Flaps; Head and Neck Neoplasms; Mandibular Reconstruction; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microsurgery; Neck Dissection; Oncology; Organoids; Primary Cell Culture; Receptors, Interleukin-6; Reconstructive Surgical Procedures; Spheroids, Cellular; Translational Medical Research

Research group(s)

  • Basic Oncology Research in Head and Neck Cancer
    Members:
  • Hirtler Lab
    Head: Lena Hirtler
    Research Area: The members of this research group address a wide range of anatomical and clinical-morphological questions. Starting from classical anatomical and histological evaluations to clinical applications, e.g. minimally invasive surgery and imaging procedures, research questions are processed by the use of state-of-the-art techniques. Apart from stand-alone projects, the group is characterized by collaborations with a variety of partners to tackle currently relevant issues in clinical practice.
    Members:

Research interests

  • Translational research
  • patient-derived head and neck sqamous cell carcinoma (HNSCC) culture (cultivating and engineering HNSCC-organoids and spheroids)
  • patient-derived xenografts (PDX)
  • organoid-derived grafts (ODX)
  • 4-NQO mouse model
  • Tumor microenvironment (TME)
  • influence of TME on cancer chemo- and radioresistance
  • Autophagy
  • role of autophagy in cancer development and response to chemo- and radiotherapy
  • Extracellular matrix (ECM)
  • creating scaffolds and hydrogels derived from animals and humans for in vitro applications
  • influence of ECM on HNSCC tumor progression and invasion
  • Thin section histology
  • Methylmethacrylat-based histology to analyse implant-tissue-interactions

Techniques, methods & infrastructure

  • Thin-section histology (Division of Anatomy)
  • Endoscopic surgery (Division of Anatomy)
  • Microscopic surgery (Surgical microscope at Division of Anatomy)
  • Cell Culture (Biosafety 2 Lab, Department of Otorhinolaryngology)

Grants

  • Targeting autophagy and evaluation of its effect in head and neck cancer spheroids (2023)
    Source of Funding: Margarethe Hehberger Stiftung, Malignant Diseases
    Principal Investigator

Selected publications

  1. Kandathil, S.A. et al. (2024) ‘The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review’, Journal of Cancer Research and Clinical Oncology, 150(2). Available at: https://doi.org/10.1007/s00432-023-05514-3.
  2. Kandathil, S.A. et al. (2024) ‘Hotspots of facial artery perforators and perforasomes for easier flap guidance: An anatomical study’, Annals of Anatomy - Anatomischer Anzeiger, 252, p. 152205. Available at: https://doi.org/10.1016/j.aanat.2023.152205.
  3. Kandathil, S.A., Dengler, L.S. and Hirtler, L. (2024) ‘First standardized assessment of perforators and perforasomes of the occipital artery – An anatomical study’, Annals of Anatomy - Anatomischer Anzeiger, 254, p. 152241. Available at: https://doi.org/10.1016/j.aanat.2024.152241.
  4. Roccuzzo, G. et al. (2024) ‘Endoscopic‐assisted transorbital extended orbital exenteration: A multi‐institutional preclinical study’, Head & Neck, 46(9), pp. 2327–2339. Available at: https://doi.org/10.1002/hed.27858.
  5. Schwarz, G.M. et al. (2024) ‘Three-Dimensional Osseointegration Patterns of Cementless Femoral Stems’, Journal of Bone and Joint Surgery, 106(11), pp. 941–949. Available at: https://doi.org/10.2106/jbjs.23.00526.