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SFB F70 International Symposium: "Translating T cell immunology: Histone deacetylases - from basic research to clinical application"

19. - 20.09.2022, Van-Swieten Saal, Medical University of Vienna

19. September 2022
9:15 - 17:45

20. September 2022
9:15 - 12:45

Medical University of Vienna
Van Swieten Saal
Van-Swieten-Gasse 1a, 1090 Wien

International symposium of the special research program (SFB F70) "HDACs as regulators of T cell-mediated immunity in health and disease”

For our international symposium "Translating T cell immunology: Histone deacetylases - from basic research to clinical application" we have assembled a great line-up of speakers with talks covering chromatin & epigenetics, HDAC biology and function, clinical application of epigenetic inhibitors as well as a special session dedicated on characterizing regulatory mechanisms of T cell-mediated immunity using OMICS approaches.


List of Speakers

  • Wayne Hancock
    University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA
  • Johan Henriksson
    Karolinska Institutet, Huddinge, Sweden
  • Andrew Howden
    University of Dundee, Dundee, UK
  • Ricky W. Johnstone
    University of Melbourne, Parkville, Australia
  • Felix Meissner
    University of Bonn, Bonn, Germany
  • Alexander Rudensky
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
  • John Schwabe
    Leicester Institute of Structural and Chemical Biology, Leicester, UK
  • Christian Seiser
    Medical University of Vienna, Austria
  • Virginia Shapiro
    Mayo Clinic, Rochester, Minnesota, MN, USA
  • Golnaz Vahedi
    University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA
  • Femke van Wijk
    University Medical Center Utrecht, Utrecht, The Netherlands
  • Anton Wutz
    Swiss Federal Institute of Technology - ETH, Zurich, Switzerland

Programme

09:15 - 10:50 Session I: Chromatin & epigenetics
Chairs: Christian Seiser & Michael Bonelli

  • 09:15 - 09.20 Welcome           
  • 09:20 - 10:05 Anton WUTZ: Histone deacetylase and nucleosome assembly complexes contribute to X chromosome inactivation in mouse embryonic stem cells
  • 10:05 - 10:50 Golnaz VAHEDI: A multi-enhancer hub endows competence for T cell differentiation

10:50 - 11:20 coffee break

11:20 - 12:50 Session II: HDAC - function & structure 
Chairs: Karl Kuchler & Wolfgang Reiter

  • 11:20 - 12:05 John SCHWABE: Diverse structures, mechanisms and functions of class I HDAC complexes
  • 12:05 - 12:50 Christian SEISER: Set-up of genetic models mimicking isoform-specific class I HDAC inhibitors

12:50 - 14:00 lunch break: lunch provided

14:00 - 15:45 Session III: HDAC-mediated control of T cell immunity   
Chairs: Thomas Krausgruber & Valentina Stolz

  • 14:00 - 14:45 Virginia SHAPIRO: HDAC3 represses cholesterol efflux during CD4 T cell activation
  • 15:00 - 15:45 Wanye HANCOCK: Why Do Tregs Express Both HDAC1 and HDAC2, With Opposite Effects on Treg Function, in at Least 3 Multiprotein Coregulatory Complexes?”

15:45 - 16:15 coffee break

16:15 - 17:45 Session IV: Epigenetics and Clinical application
Chairs: Iris Gratz & Ashley Zhu

  • 16:15 - 17:00 Femke VAN WIJK: Human Treg adaptation; location matters, …. or not?
  • 17:00 - 17:45 Ricky W JOHNSTONE: Altered histone acetylation dynamics regulates tumor and immune cell phenotype and functions

09:15 - 12:05 Session IV: OMICS approaches in immunology  
Chairs: Nicole Boucheron & Markus Hartl

  • 09:15 - 10:00 Andrew HOWDEN: Mapping T cell environment sensors and signalling pathways using quantitative proteomics
  • 10:00 - 10:45 Felix MEISSNER: Decoding Intercellular Immune Signaling Networks by Quantitative Proteomics
  • 10:45 - 11:15 coffee break
  • 11:15 - 12:05 Johan HENRIKKSON: Interpreting single-cell multiomics: new readouts and machine learning

12:00 - 13:00 CLOSING Session – keynote lecture
Chairs: Wilfried Ellmeier & Teresa Preglej

  • Alexander RUDENSKY: Peripheral differentiation of Treg cells

Registration

We cordially invite all interested colleagues to attend our symposium. Attendance will be free of charge, however is limited to a total number of 150 participants. Please use the registration form below if you plan to attend.

Data protection declaration in accordance with the General Data Protection Regulation: Your data will only be used to process your participation in the event and will be deleted after the storage period has expired in accordance with the GDPR.
» Further information

Note: We would like to point out that photos and / or videos might be taken / recorded at the venue. These can be published in print and online media, on various social media platforms and on the website of MedUni Vienna and University Hospital Vienna for the purpose of documenting and reporting on the event.


Covid Regulations

We recommend wearing an FFP2 mask during the event. Covid positive tested individuals are not allowed to participate in the event.


Contact

HIT

Wilfried Ellmeier

Institute of Immunology