Jubilee Meeting: 25 Years WHO Classification of Mastocytosis
Programm
Thursday, August 21, 2025
19:00 Welcome Reception
Friday, August 22, 2025
8:15 Welcome Coffee
8:40 Welcome, Introduction and Overview
Peter Valent, Vienna, Austria
9:00 Session I: Pathology and Morphology
Chairs: M. Arock & M. Triggiani
9:00 Application of Diagnostic SM Criteria by the Pathologist
Karl Sotlar, Salzburg Austria
9:20 Special, Unusual and Novel Sub-Variants of SM
Hans-Peter Horny, Munich, Germany
9:40 Morphologic Grading of the Mast Cell Lineage in SM
Wolfgang R. Sperr, Vienna, Austria
10:00 Coffee Break
10:30 Session II: Serologic, Molecular and Immunologic Markers
Chairs: P. Valent & D.D. Metcalfe
10:30 From Tryptase to Hereditary Alpha Tryptasemia in SM
Lawrence B. Schwartz, Richmond, VA, USA
10:50 KIT Mutation Analysis in Mast Cell Neoplasms: Status 2025
Michel Arock, Paris, France
11:10 Prognostication of SM by Phenotyping, Genotyping, and Scoring
Alberto Orfao, Salamanca, Spain
11:30 Mutational Landscapes in SM and Related Myeloid Neoplasms
Gregor Hoermann, Munich, Germany
11:50 Historical Remarks by Peter Valent
12:00 Lunch Break
13:30 Session III: Mast Cell Activation and MCAS
Chairs: O. Hermine & L.B. Schwartz
13:30 Signaling Pathways Triggering Mast Cell Activation
Dean D. Metcalfe, Bethesda, MD, USA
13:50 From Mast Cell Activation to MCAS and MMAS
Cem Akin, Ann Arbor, MI, USA
14:10 Treatment of MC Activation in CM, BMM and ISM by
KIT-directed TKI and other Drugs
Karin Hartmann, Basel, Switzerland
14:30 In vitro Assays to Measure MC and Basophil Activation
Massimo Triggiani, Salerno, Italy
14:50 Coffee Break
15:20 Session IV: Potential Pre-Phases of SM
Chairs: K. Hartmann & C. Akin
15:20 Initial Events and Clonal Diversification in SM
Andreas Reiter, Mannheim, Germany
15:40 Pre-Phases of SM and Development of Preventive Strategies
Peter Valent, Vienna, Austria
16:00 Proposed Potential Pre-Phases of SM: Update 2025
Olivier Hermine, Paris France
16:20 Coffee Break
16:50 Session V: Case Presentations and Hot Topics
Chairs: K. Sotlar & A. Orfao
16:50 Luis Escribano, Madrid, Spain: Personal Remarks
17:00 Julien Rossignol, Paris, France: An Unusual Case of SM
17:10 Frank Siebenhaar, Berlin, Germany: MASTHAVE
17.20 Karoline V. Gleixner, Vienna, Austria: A Case of MCS
17:30 Vito Sabato, Antwerp, Belgium: Familial HaT and MCAS
18:00 Max Vincent John, Vienna, Austria: SM and F/P+ CEL
18:10 Summary of Meeting and Final Remarks
Peter Valent, Vienna, Austria
19:00 25 Years Celebration and Faculty Dinner