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Nicole Eder-Nesvacil
Assoc. Prof. Mag. Dr. Nicole Eder-Nesvacil

Department of Radiation Oncology
Position: Associate Professor

ORCID: 0000-0002-7920-7754
T +43 1 40400 26650

Further Information


Brachytherapy; Dose-Response Relationship, Radiation; Evidence-Based Medicine; Gynecology; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Quality Assurance, Health Care; Radiation Oncology; Ultrasound, High-Intensity Focused, Transrectal; Uncertainty

Research group(s)

Research interests

My main research focus is to improve the state of the art of image-guided adaptive brachytherapy for gynaecological cancer, by development of modern software tools to facilitate access to clinical evidence for the relation of technical treatment parameters with clinical outcome. I am part of the international group which runs the EMBRACE studies for cervical cancer, as well as the GEC-ESTRO gyn network. Furthermore, I work on image-registration applications for therapy planning and therapy monitoring for brachytherapy.

In addition, I am part of a team who works on translating the state of the art method for 3D imaging for gynaecological brachytherapy - which is MRI - to settings with limited access to MRI. Ultrasound is a promising tool to image target volumes essential for brachytherapy treatment. In combination with CT for treatment planning. ultrasound has the potential to be widely used in high volume centers, and allow for precision brachytherapy to be applied for a vast number of patients.


  • Evidence-based decision making for image-guided brachytherapy (2018)
    Source of Funding: FWF (Austrian Science Fund), Programme Clinical Research
    Principal Investigator

Selected publications

  1. Pötter, R. et al. (2021) ‘MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study’, The Lancet Oncology, 22(4), pp. 538–547. Available at:
  2. Schmid, M.P. et al. (2023) ‘Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image–Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study’, Journal of Clinical Oncology, 41(10), pp. 1933–1942. Available at:
  3. Westerveld, H. et al. (2020) ‘Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer’, The Lancet Oncology, 21(3), pp. e157–e167. Available at:
  4. Ecker, S. et al. (2023) ‘EviGUIDE - a tool for evidence-based decision making in image-guided adaptive brachytherapy for cervical cancer’, Radiotherapy and Oncology, 186, p. 109748. Available at:
  5. Ecker, S. et al. (2023) ‘Tools for large-scale data analytics of an international multi-center study in radiation oncology for cervical cancer’, Radiotherapy and Oncology, 182, p. 109524. Available at: