Detail

Keywords

Cartilage; Diffusion Magnetic Resonance Imaging; Film Dosimetry; Magnetic Resonance Imaging; Microscopy; Multimodal Imaging; Polymers; Quality Control; Radiation Oncology; Tendons; Thermoluminescent Dosimetry; Ultrahigh field MRI

Research group(s)

• Magnetic Resonance Microimaging and -Microscopy
  Research Area: Magnetic Resonance (MR)-micro-imaging and -microscopy on a human high-field MR scanner: Implementations (Hardware), quality control and Bio-medical applications
  Members:
  Andreas Berg

Research interests

Parameter selective Magnetic Resonance (MR) Micro-Imaging and MR-Microscopy:
1.) Hardware and Software Development
2.) Quality control
3.) Applications:

• Polymer-gel-dosimetry for radiation therapy
• Imaging of the MR-invisible in clinical imaging (e.g. hard tissue, teeth)
• Imaging of Biocompatible material (e.g. plastics) and its degradation
• MR-based-histology
• High-resolution invivo µ-imaging
• New MR-microscopy applications

Techniques, methods & infrastructure

1.) Hardware:

• High-field (B = 7T) Magnetic Resonance Imaging (MRI) -scanner;
• Magnetic Resonance Microscopy insert;
• Simple chemical lab

2.) Measurement techniques:

• Parameter selective imaging for different contrasts:
• spin density, T2, T1, diffusivity, fat- + water-saturation, Magnetization transfer,..

3.) Special techniques:

• Magnetic Resonance microscopy and micro-imaging
• Ultrashort detection time imaging (UTE)
• Polymer gel dosimetry

Selected publications

1. A. Berg, A. Potthast, P. Starewicz; MR-MICROSCOPY ON A HUMAN 7T-SCANNER; Proc. ISMRM/ESMRMB, Stockholm, Sweden, 01.-07.05.2010; Progr nr. 1048, (2010).
2. A. Berg, M. Stoiber, X. Deligianni, O. Bieri; T2*-mapping of tendon µ-structure changes after mechanical load in an adult bovine animal model using vTE pulse sequences: the role of resolution up to microscopic scale in quantification; Magnetic Resonance Materials in Physics, Biology and Medicine 30 (Suppl 1): S106-S107 (2017)
3. Khan, M. et al., 2019. Basic Properties of a New Polymer Gel for 3D-Dosimetry at High Dose-Rates Typical for FFF Irradiation Based on Dithiothreitol and Methacrylic Acid (MAGADIT): Sensitivity, Range, Reproducibility, Accuracy, Dose Rate Effect and Impact of Oxygen Scavenger. Polymers, 11(10), p.1717 (2019) https://www.mdpi.com/2073-4360/11/10/1717
4. Schwerdtfeger, M. et al., 2012. Terahertz time-domain spectroscopy for monitoring the curing of dental composites. Biomed. Opt. Express, 3(11), p.2842 (2012). https://www.osapublishing.org/boe/abstract.cfm?uri=boe-3-11-2842
5. A. Berg, G. Heilemann, D. Georg MR-µ-imaging based 3-dimensional-polymer gel dosimetry in comparison to 2D-film and 1D-diamond dosimetry of mm-sized photon pencil beams; Biomedical Engineering-Biomedizinische Technik 62(s1) S519 (sept 2017) https://doi.org/10.1515/bmt-2017-5099