Skip to main content English

Detail

Cecile Philippe
Mag. Dr. Cecile PhilippeUniv.-Assistant

Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Research Associate (Postdoc)

ORCID: 0000-0002-7203-7174
T +43 1 40400 20340
cecile.philippe@meduniwien.ac.at

Further Information

Keywords

Drug Evaluation, Preclinical; Molecular Imaging; Positron-Emission Tomography; Radioactive Tracers

Research interests

Biomedical Imaging and Tracer Development

My main area of research is the preclinical development and evaluation of radiopharmaceuticals with focus on energy metabolism and immunology. Thereby, I am focusing on following targets:

  • Melanin Concentrating Hormone Receptor 1 (MCHR1)
  • Glucose and fatty acid metabolism
  • ED-B Fibronectin
  • T-cells
  • Fibroblast Activation Protein (FAP)
  • Folate Receptor alpha (FRa)

My expertise rages from radiochemistry to non-invasive molecular imaging and ex vivo analyses.

Techniques, methods & infrastructure

Techniques:

  • Radiosynthesis
  • Binding-studies (cell culture)
  • Metabolism
  • Blood-brain-barrier penetration
  • Autoradiography
  • Immunhistochemistry
  • Small animal PET/CT/MRI
  • Biodistribution
  • Genotyping
  • PCR
  • MACS
  • FACS

 Access to the Preclinical Imaging Laboratory (FELASA certificate).

Selected publications

  1. Philippe, C. et al., 2018. SNAPshots of the MCHR1: a Comparison Between the PET-Tracers [18F]FE@SNAP and [11C]SNAP-7941. Molecular Imaging and Biology. Available at: http://dx.doi.org/10.1007/s11307-018-1212-0.
  2. Zeilinger, M. et al., 2017. In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [11C]SNAP-7941 and [18F]FE@SNAP reveal specific uptake in the ventricular system. Scientific Reports, 7(1). Available at: http://dx.doi.org/10.1038/s41598-017-08684-6.
  3. Philippe, C. et al., 2014. Comparative autoradiographic in vitro investigation of melanin concentrating hormone receptor 1 ligands in the central nervous system. European Journal of Pharmacology, 735, pp.177-183. Available at: http://dx.doi.org/10.1016/j.ejphar.2014.04.020.
  4. Philippe, C., Klebermass, E.M., et al., 2021. Discovery of melanin-concentrating hormone receptor 1 in brown adipose tissue. Ann N Y Acad Sci. 1494:70-86
  5. Philippe, C. et al., 2015. Parameter evaluation and fully-automated radiosynthesis of [11C]harmine for imaging of MAO-A for clinical trials. Applied Radiation and Isotopes, 97, pp.182-187. Available at: http://dx.doi.org/10.1016/j.apradiso.2015.01.002.