Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: PHD Student
ORCID: 0000-0002-1464-9383
T +43 1 40400-58736
usevalad.ustsinau@meduniwien.ac.at
Keywords
Energy Metabolism; Multimodal Imaging; Obesity; Positron-Emission Tomography
Research group(s)
- Experimental Nuclear Medicine
Head: Cécile Philippe
Research Area: The research group "Experimental Nuclear Medicine" deals with the development and evaluation of radiotracers in various diseases. In addition, the group focuses on organ axes and pharmacokinetics.
Members:
Research interests
My primary focus is centered around the evaluation of metabolic disorders. The role of energy metabolism in the development of various ailments, such as obesity, Type 2 Diabetes Mellitus, and Non-alcoholic Fatty Liver Disease (NAFLD), has been recently well-established. In this regard, I am interested in exploring the use of functional imaging techniques in nuclear medicine to detect variations in tracer kinetics in both clinical and preclinical models.
Techniques, methods & infrastructure
My expertise lies in managing the entire preclinical PET imaging process from start to finish. This includes producing radiotracers (labeling with 18F), handling animals safely with a FELASA certificate, establishing hybrid PET imaging protocols, and processing the resulting signal and images using software such as Pmod, Hermes, ITK Snap, Carimas and others.
Selected publications
- Ustsinau, U. et al. (2023) ‘Novel approach using [18F]FTHA-PET and de novo synthesized VLDL for assessment of FFA metabolism in a rat model of diet induced NAFLD’, Clinical Nutrition, 42(10), pp. 1839–1848. Available at: https://doi.org/10.1016/j.clnu.2023.08.001.
- Ustsinau, U. et al. (2024) ‘A Fully Automated Synthesis of 14-(R,S)-[18F]fluoro-6-thia-heptadecanoic Acid ([18F]FTHA) on the Elixys Radiosynthesizer’, Pharmaceuticals, 17(3), p. 318. Available at: https://doi.org/10.3390/ph17030318.
- Ustsinau, U. et al. (2024) ‘A PET/MRI study on the effect of obesity and NAFLD on hepatic [18F]FDG uptake’, European Journal of Radiology, p. 111552. Available at: https://doi.org/10.1016/j.ejrad.2024.111552.