Magnetic Resonance Spectroscopy; Multiple Sclerosis; Neurodegeneration; Neuroinflammation; Rare Diseases; Ultrahigh field MRI
- High Field Magnetic Resonance Imaging and Spectroscopy
Research Area: musculoskeletal MR; neuroimaging; metabolic MR imaging and spectroscopy
- Molecular Magnetic Resonance Imaging
Head: Wolfgang Bogner
Research Area: Development and clinical evaluation of Molecular Magnetic Resonance Imaging techniques at high (3T) and ultra-high (7T) human whole-body MR scanners
During my PhD studies supervised by Prof. Bogner I mainly worked on the clinical translation of high-resolution MR spectroscopic imaging. Particularly, I was interested in its application to multiple sclerosis brains, where high-resolution metabolic imaging of myo-inositol and N-acetyl aspartate allows to visualize focal and diffuse pathology in white matter which appears inconspicuous on clinical MRI and shows correlation with clinical disability status of patients.
As a postdoctoral researcher I continue to expand my interest in advanced multi-parametric MRI applications to a wider scope of demyelinating, neurodegenerative and rare inherited disorders, which hopefully contributes to their better understanding, diagnosis, monitoring and treatment.
Techniques, methods & infrastructure
- High-resolution whole-brain MR Spectroscopic imaging
- Multiparametric MRI and MRSI applications to patient studies
- Advanced MRI methods at 3T and 7T
- Heckova, E. et al. (2022) ‘Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis’, Radiology, 303(1), pp. 141–150. Available at: http://dx.doi.org/10.1148/radiol.210614.
- Heckova, E. et al. (2019) ‘7 T Magnetic Resonance Spectroscopic Imaging in Multiple Sclerosis’, Investigative Radiology, 54(4), pp. 247–254. Available at: http://dx.doi.org/10.1097/rli.0000000000000531.
- Heckova, E. et al. (2018) ‘Real-time Correction of Motion and Imager Instability Artifacts during 3D γ-Aminobutyric Acid–edited MR Spectroscopic Imaging’, Radiology, 286(2), pp. 666–675. Available at: http://dx.doi.org/10.1148/radiol.2017170744.
- Heckova, E. et al. (2019) ‘Effects of different macromolecular models on reproducibility of FID‐MRSI at 7T’, Magnetic Resonance in Medicine, 83(1), pp. 12–21. Available at: http://dx.doi.org/10.1002/mrm.27922.
- Gruber, S. et al. (2017) ‘Mapping an Extended Neurochemical Profile at 3 and 7 T Using Accelerated High-Resolution Proton Magnetic Resonance Spectroscopic Imaging’, Investigative Radiology, 52(10), pp. 631–639. Available at: http://dx.doi.org/10.1097/rli.0000000000000379.