Department of Biomedical Imaging and Image-guided Therapy
Position: Research Associate (Postdoc)
ORCID: 0000-0003-1235-7595
T +43 1 40400 64680
fabian.niess@meduniwien.ac.at
Keywords
Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy
Research group(s)
- High Field Magnetic Resonance Imaging and Spectroscopy
Research Area: musculoskeletal MR; neuroimaging; metabolic MR imaging and spectroscopy
Members: - Molecular Magnetic Resonance Imaging
Head: Wolfgang Bogner
Research Area: Development and clinical evaluation of Molecular Magnetic Resonance Imaging techniques at high (3T) and ultra-high (7T) human whole-body MR scanners
Members:
Research interests
Deuterium metabolic imaging is a novel Magnetic Resonance technique to non-invasively assess glucose uptake and downstream metabolism of healthy and pathologic tissue. It can be potentially used as a method for early therapy response monitoring for, e.g., cancer patients, therefore my main research interest is to develop novel methods to improve the image quality and resolution of DMI methods using direct (2H) or indirect (1H) deuterium detection.
Techniques, methods & infrastructure
- Non-invasive mapping of brain glucose metabolism using 2H Deuterium Metabolic Imaging (DMI) and 1H Quantitative Exchange Label Turnover (QELT) MRSI
- Pulse sequence development (Siemens IDEA) and data processing for MR spectroscopy and imaging at high field (3 T) and ultra high field (7 T)
- Interleaved multi-nuclear data acquisition
Grants
- Imaging dynamics of glioma metabolism via MRI (2022)
Source of Funding: FWF (Austrian Science Fund), KLIF
Principal Investigator
Selected publications
- Niess, F. et al. (2024) ‘Whole‐brain deuterium metabolic imaging via concentric ring trajectory readout enables assessment of regional variations in neuronal glucose metabolism’, Human Brain Mapping, 45(6). Available at: https://doi.org/10.1002/hbm.26686.
- Niess, F. et al. (2023) ‘Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (2H) and indirect (1H) detection of deuterium labeled compounds at 7T and clinical 3T’, NeuroImage, 277, p. 120250. Available at: https://doi.org/10.1016/j.neuroimage.2023.120250.
- Niess, F. et al. (2023) ‘Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T’, Investigative Radiology, 58(6), pp. 431–437. Available at: https://doi.org/10.1097/rli.0000000000000953.
- Bednarik, P. et al. (2023) ‘1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain’, Nature Biomedical Engineering, 7(8), pp. 1001–1013. Available at: https://doi.org/10.1038/s41551-023-01035-z.
- Niess, F. et al. (2019) ‘Interleaved 31P MRS/1H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T’, Magnetic Resonance in Medicine, 83(6), pp. 1909–1919. Available at: https://doi.org/10.1002/mrm.28088.