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Fabian Niess
Dipl.-Ing. Fabian Niess, PhD

Department of Biomedical Imaging and Image-guided Therapy
Position: Research Associate (Postdoc)

ORCID: 0000-0003-1235-7595
T +43 1 40400 64680
fabian.niess@meduniwien.ac.at

Further Information

Keywords

Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy

Research group(s)

Research interests

I am a biomedical engineer by training and focused during my master thesis and my PhD studies mainly on pulse sequence development. A simultaneous acquisition of proton and X-nuclei signals was theoretically feasible, but required hardware/software modification, which ultimatively became the main focus of my PhD thesis.

The combination of two individual pulse sequences (1H Arterial Spin Labelling MRI and 31P semi-laser MR spectroscopy), allowed for a simultaneous assessment of dynamic perfusion, T2*-weighted and metabolic data and overall resulted in three individual first author manuscripts (MRM 2017 and 2020, NMR in Biomed 2018). Following my PhD I implemented a double quantum filter 1H MR spectroscopy sequence for application on both 3T and 7T Siemens systems to non-invasively detect lactate in muscle tissue throughout voluntary exercise, which was published in another first author publication (MRM 2022).

Recently i focused on developing a non-invasive method to assess brain glucose downstreeam metabolism dynamically after oral adminisration of deuterium labeled glucose. Using direct (2H DMI) and indirect (1H QELT MRSI) deuterium detection, allowed for a fully non-invasive assessment of glucose uptake and neurotransmitter synthesis in the brain tissue, leading to two additional first author publications (Investigative Radiology 2023 and Neuroimage 2023).

Techniques, methods & infrastructure

  • Non-invasive mapping of brain glucose metabolism using 2H Deuterium Metabolic Imaging (DMI) and 1H Quantitative Exchange Label Turnover (QELT) MRSI
  • Pulse sequence development (Siemens IDEA) and data processing for MR spectroscopy and imaging at high field (3 T) and ultra high field (7 T)
  • Dynamic 31P spectroscopy and time resolved 1H perfusion imaging in skeletal muscle tissue
  • Resting and post exercise lactate quantification using 1H Double Quantum Filtered MR spectroscopy
  • Interleaved multi-nuclear data acquisition


Grants

Selected publications

  1. Niess, F. et al. 2023 Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (2H) and indirect (1H) detection of deuterium labeled compounds at 7T and clinical 3T, NeuroImage, 277, p. 120250. Available at: http://dx.doi.org/10.1016/j.neuroimage.2023.120250.
  2. Niess, F. et al. 2023 Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T, Investigative Radiology, 58(6), pp. 431–437. Available at: http://dx.doi.org/10.1097/rli.0000000000000953.
  3. Bednarik, P. et al. 2023 1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7T in the human brain, Nature Biomedical Engineering. Available at: http://dx.doi.org/10.1038/s41551-023-01035-z.
  4. Niess, F. et al. 2022 3D localized lactate detection in muscle tissue using double‐quantum filtered 1H MRS with adiabatic refocusing pulses at 7T, Magnetic Resonance in Medicine, 87(3), pp. 1174–1183. Available at: http://dx.doi.org/10.1002/mrm.29061.
  5. Niess, F. et al. 2020 Interleaved 31P MRS/1H ASL for analysis of metabolic and functional heterogeneity along human lower leg muscles at 7T’, Magnetic Resonance in Medicine, 83(6), pp. 1909–1919. Available at: http://dx.doi.org/10.1002/mrm.28088.