Detail

Keywords

Bioprinting; Cell- and Tissue-Based Therapy; Drug Delivery Systems; Guided Tissue Regeneration

Research group(s)

• Enayati-Lab
  Head: Bruno Podesser
  Research Area: My team and I focus on developing and characterizing biomaterials for cardiovascular tissue engineering, with emphasis on biocompatibility and in vitro/in vivo functional validation. Our work includes cardiac patches, mitral annuloplasty rings, and small-diameter vascular grafts. We also explore 3D bioprinting, immunomodulatory biomaterials, and biofunctionalized systems for controlled drug delivery and tissue regeneration.
  Members:
  Marjan Enayati

Research interests

• Biomaterials development for cardiovascular tissue engineering, focusing on biocompatibility and in vitro/in vivo validation, including cardiac patches, mitral rings, and SDVGs.
• 3D bioprinting of polymeric scaffolds for advanced tissue engineering.
• Immunomodulatory biomaterials for improved integration and regeneration.
• Biofunctionalized scaffolds for targeted, sustained drug delivery.

Techniques, methods & infrastructure

• In vitro cell-based assays: 2D/3D cell culture, biocompatibility, biodegradation, and mechanical assessment
• Inflammatory and immunological evaluation: predictive models and macrophage interaction studies
• Advanced imaging: immunofluorescence (IF) microscopy
• 3D manufacturing: bioplotting and additive manufacturing of biomaterial scaffolds
• In vivo preclinical studies: small and large animal models

Selected publications

1. Enayati, M. et al. (2025) ‘3D printed cardiac patch coated with human extracellular matrix hydrogel: Significant improvement of cell adhesion and immune reaction’, International Journal of Bioprinting, 0(0), p. 6383. Available at: https://doi.org/10.36922/ijb.6383.
2. Enayati, M. et al. (2021) ‘S-nitroso human serum albumin as a nitric oxide donor in drug-eluting vascular grafts: Biofunctionality and preclinical evaluation’, Acta Biomaterialia, 134, pp. 276–288. Available at: https://doi.org/10.1016/j.actbio.2021.07.048.
3. Enayati, M. et al. (2020) ‘Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft’, Journal of the Mechanical Behavior of Biomedical Materials, 112, p. 104077. Available at: https://doi.org/10.1016/j.jmbbm.2020.104077.
4. Eilenberg, M. et al. (2020) ‘Long Term Evaluation of Nanofibrous, Bioabsorbable Polycarbonate Urethane Grafts for Small Diameter Vessel Replacement in Rodents’, European Journal of Vascular and Endovascular Surgery, 59(4), pp. 643–652. Available at: https://doi.org/10.1016/j.ejvs.2019.11.004.
5. Ferreira, S.A. et al. (2018) ‘Bi-directional cell-pericellular matrix interactions direct stem cell fate’, Nature Communications, 9(1). Available at: https://doi.org/10.1038/s41467-018-06183-4.