Detail

Keywords

Colorectal Neoplasms; Innate Immunity; Liver; Macrophages; Receptors, Natural Killer Cell

Research group(s)

• Surgical Research Laboratories
  Head: Michael Bergmann
  Research Area: The task of the laboratory is to combine molecular/cellular biology and the needs posed by surgical patients. Thus, the laboratory acts at the interface between clinical medicine and basic research, promoting translational medical science.
  Members:
  Daniela Kandioler
  Lindsay Hargitai
  Christopher Dawoud
  Joy Feka
  Bernhard Moser
  Johannes Längle
  Christoph Schwarz
  Rebecca Zirnbauer
  Lukas Unger
  Michael Bergmann
  Felix Harpain
  Nina Pilat-Michalek
  Rudolf Oehler
  Jakob Mühlbacher
  Victoria Stary

Techniques, methods & infrastructure

• Immunohistology, including immunofluorescence microscopy and Fluorescence in situ hybridization (FISH)
• FACS (including intracellular cytokine staining)
• Cell isolation from various organs by flow cytometry (up to single-cell sorting) or microbeads
• Cell culture and functional assays with low input cell numbers (including cytokine stimulation, proliferation assays, migration assays, cytotoxicity assays)
• ELISA
• Quantitative RT-PCR
• Single cell sequencing in cooperation with CeMM

Selected publications

1. Stary, V. et al. (2024) ‘Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer’, Nature Communications, 15(1). Available at: https://doi.org/10.1038/s41467-024-51025-1.
2. Stary, V. et al. (2020) ‘A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses’, Science Immunology, 5(52). Available at: https://doi.org/10.1126/sciimmunol.aba6232.
3. Stary, V. et al. (2020) ‘Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer’, Journal for ImmunoTherapy of Cancer, 8(2), p. e000667. Available at: https://doi.org/10.1136/jitc-2020-000667.
4. Stary, V. and Stary, G. (2020) ‘NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?’, Frontiers in Cellular and Infection Microbiology, 10. Available at: https://doi.org/10.3389/fcimb.2020.00208.
5. Stary, V. et al. (2016) ‘SERCA2a upregulation ameliorates cellular alternans induced by metabolic inhibition’, Journal of Applied Physiology, 120(8), pp. 865–875. Available at: https://doi.org/10.1152/japplphysiol.00588.2015.